Lower vs higher ketamine doses to reduce the oculocardiac reflex in eye surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares two intravenous doses of ketamine (0.5 mg/kg vs 0.75 mg/kg) given during elective ophthalmic surgery under general anesthesia to see which dose better reduces the oculocardiac reflex. The OCR can cause bradycardia or other heart changes during eye muscle traction or eye pressure. The trial focuses on adult patients aged 18–65 with ASA I–II, and excludes those with ketamine contraindications or certain eye or heart conditions. Outcomes include OCR incidence and potential side effects related to ketamine emergence and psychomimetic effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 18 to 65 years old.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status I, II.
* Scheduled for elective ophthalmic surgery involving extraocular muscle traction under general anesthesia.

Exclusion Criteria:

* Ketamine contraindications (e.g., hypersensitivity, uncontrolled hypertension)
* History of cardiac arrhythmia or conduction disorder
* Glaucoma or raised intraocular pressure
* ASA status greater than II
* Patient refusal.

Where it's running

• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Hebatullah S Abdelhamid, MD
• Email: drhebasalah593@gmail.com
• Phone: 00201044512277

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.