Which pre‑induction medicine causes less coughing: tegilidine or sufentanil
Official title: The Affiliated Lianyungang Hospital of Xuzhou Medical University
Run by The First People's Hospital of Lianyungang · NCT07323043 · Data updated 2026-11-12
This will see if tegilidine or sufentanil causes less coughing when given before general anesthesia in adults having planned tracheal intubation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 190 (estimated) |
| Sponsor | The First People's Hospital of Lianyungang Academic / other |
| Locations | 1 site (Lianyungang, Jiangsu) |
| Status | Recruiting |
| Started | January 15, 2026 |
| Main results expected | August 16, 2026 |
| Study ends | October 13, 2026 |
| Registry record updated | July 8, 2026 |
| Trial ID | NCT07323043 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with BMI 18–30 kg/m2, ASA I–III, scheduled for elective surgery under general anesthesia with planned tracheal intubation are ideal candidates.
✕Probably not a fit
Patients with chronic cough or asthma, severe cardiovascular, intracranial, eye, or lung disease, or known allergy to the study drugs are excluded and are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized, double‑blind, controlled comparison of tegilidine versus sufentanil given before induction of general anesthesia. Adult patients are randomly assigned to receive tegilidine (20–50 µg/kg) or sufentanil (0.4 µg/kg) after standard monitoring and preoxygenation, with no other drugs given beforehand. Cough is observed and graded two minutes after injection using a four‑grade scale based on frequency and duration. The study is single‑center and records the incidence and severity of cough during the induction period.
Why it matters
Potential benefit: If successful, the results could identify a pre‑induction agent that reduces coughing during intubation, improving patient comfort and reducing airway or hemodynamic complications.
How similar studies have gone: Opioid‑induced cough (for example with fentanyl or sufentanil) has been documented and various mitigation strategies have been tested, but direct comparisons between tegilidine and sufentanil are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age between 18 and 65 years, 18 ≤ BMI (kg/m²) ≤ 30; 2. ASA grade I \~ III; 3. Scheduled elective surgery under general anesthesia with tracheal intubation. Exclusion Criteria: 1. Patients with chronic cough (cough lasting \>8 weeks) or asthma; 2. Patients with a history of allergy to the drugs used during the study; 3. Patients with severe cardiovascular disease, intracranial lesions, eye lesions, or lung lesions.
Where it's running
-
The Affiliated Lianyungang Hospital of Xuzhou Medical University
Lianyungang, Jiangsu, China Recruiting
Study contacts
- Study coordinator: Xiaobao Zhang, Doctor
- Email: hotdog100@163.coom
- Phone: 18961322507
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.