Prone lumbar disc surgery: how breathing and brain oxygen relate
Official title: Evaluation of the Relationship Between Changes in Pulmonary Mechanics and Ventilatory Energy Load and Cerebral Oxygenation During Lumbar Disc Surgery in the Prone Position
Run by Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · NCT07862257 · Data updated 2026-11-12
This study will observe whether changes in breathing mechanics during prone lumbar disc surgery relate to brain oxygen levels in adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul, Istanbul) |
| Status | Recruiting |
| Started | September 9, 2026 |
| Main results expected | January 30, 2027 |
| Study ends | January 30, 2027 |
| Registry record updated | October 9, 2026 |
| Trial ID | NCT07862257 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 undergoing elective lumbar disc herniation surgery, able to consent, and planned for volume-controlled ventilation.
✕Probably not a fit
Patients with intracranial pathology, severe cerebrovascular disease, or significant hemodynamic instability may not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study measures how respiratory mechanics and cerebral oxygenation are linked in adults undergoing elective lumbar disc surgery in the prone position under general anesthesia. Cerebral regional oxygen saturation is monitored with bilateral frontal NIRS, while ventilation parameters such as tidal volume, respiratory rate, peak and plateau pressures, PEEP, and dynamic compliance are recorded at specific intraoperative time points. No changes to standard anesthesia, ventilation, or surgical care will be made for research purposes. The goal is to see if the prone position and intraoperative respiratory changes correlate with cerebral oxygenation during surgery.
Why it matters
Potential benefit: If a relationship is found, it could help clinicians monitor and optimize brain oxygenation during prone spine surgery.
How similar studies have gone: Previous studies in similar settings have used NIRS to monitor cerebral oxygenation and reported varying associations with respiratory parameters; this study adds direct intraoperative correlation data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-75 years * Written informed consent * Scheduled for elective lumbar disc herniation surgery * ASA physical status I-III * Volume-controlled ventilation Exclusion Criteria: * History of increased intracranial pressure * Conditions preventing placement of cerebral NIRS probes * Development of severe intraoperative complications * Significant hemodynamic instability * Known cerebrovascular disease or severe carotid artery disease * Hemoglobin \<10 g/dL or anticipated major bleeding * Severe heart failure (EF \<40%) * Advanced COPD or restrictive lung disease * Orthopedic or neurological conditions preventing tolerance of the prone position
Where it's running
-
Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Nurten Bakan Prof. Dr.
- Email: nurtenbakan@hotmail.com
- Phone: +90 216 606 33 00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.