Manual vs AutoFlow ventilation during anesthesia induction in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center randomized trial compares manual mask ventilation to AutoFlow mechanical ventilation during anesthesia induction in geriatric patients. It assesses cerebral oxygen saturation (s-rSO₂) and peripheral oxygen saturation (p-rSO₂) to determine which method provides more stable oxygen delivery during the onset of anesthesia. The study accounts for age-related physiology that can affect oxygenation and aims to identify whether a predefined, controlled ventilation strategy reduces episodes of hypoxemia or hypocapnia. Participants are adults 65+ undergoing elective surgery with endotracheal intubation, without severe cardiopulmonary disease or cognitive impairment. The trial seeks to inform best practices for airway management and intra-induction oxygenation in the elderly.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 65 years and older.
* Patients scheduled to undergo elective surgery requiring endotracheal intubation under general anesthesia.
* Patients with an American Society of Anesthesiologists (ASA) physical status of I, II, or III.
* Volunteer patients who are willing to participate and provide written informed consent.

Exclusion Criteria:

* Patients with severe heart failure or severe pulmonary disease.
* Patients with a presence or history of brain tumors or cerebrovascular accidents (CVA/stroke).
* Patients with impaired cooperation or cognitive dysfunction (e.g., dementia, delirium, Alzheimer's disease).
* Patients with a known history or preoperative prediction of a difficult airway.
* Patients with a known allergy to the monitoring sensor materials.

Where it's running

• Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation
  Ankara, Çankaya, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: FATMA G KILIÇASLAN, Resident
• Email: fatmagulgunkilicaslan@gmail.com
• Phone: +905305692877

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.