Clinical trial Recruiting at 1 site Interventional Ages 5 and up

Program to prevent rheumatic heart disease in Northern Uganda

Official title: Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda

Run by Children's Hospital Medical Center, Cincinnati · NCT05783375 · Data updated 2026-11-12

This study is testing a new program in Northern Uganda to see if it can effectively prevent Rheumatic Heart Disease in children and young adults through community screenings and local health services.

Quick facts

Study typeInterventional
Ages5 Years and up
SexAll
Enrollment221 (estimated)
SponsorChildren's Hospital Medical Center, Cincinnati
Academic / other
Locations1 site (Kampala, Uganda)
StatusRecruiting
StartedMay 1, 2024
Main results expectedJanuary 31, 2027
Study endsJanuary 31, 2028
Registry record updatedMay 15, 2026
Trial IDNCT05783375 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this program are children and young adults residing in the two involved districts in Uganda.

Probably not a fit

Patients living outside the two involved districts in Uganda may not benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study evaluates the feasibility and public health impact of a district-based program aimed at preventing Rheumatic Heart Disease (RHD) in Uganda. The initiative, known as ADUNU, implements decentralized RHD preventive services through community and facility-based echocardiographic screening for children and young adults. It also includes a registry-based secondary prophylaxis program using Benzathine penicillin G injections at local health centers. The study will assess the program's reach, effectiveness, adoption, implementation, and maintenance, as well as its cost-effectiveness.

Why it matters

Potential benefit: If successful, this program could significantly reduce the incidence of Rheumatic Heart Disease in the targeted Ugandan population.

How similar studies have gone: Other studies have shown success with similar public health initiatives aimed at preventing Rheumatic Heart Disease, indicating a promising approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* residing in one of two involved districts in Uganda
* providers at HCIIIs and HCIVs located in one of two involved Ugandan districts

Exclusion Criteria:

* None

Where it's running

  • Uganda Heart Institute
    Kampala, Uganda, Uganda
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Stop penicillin in children with mild rheumatic heart disease to see if it’s still safe

    This study tests whether stopping secondary antibiotic prophylaxis is no worse than continuing it for 2 years in kids and teens with mild rheumatic heart disease who have already been treated.

    Recruiting Phase 3 Children's Hospital Medical Center, Cincinnati · Kampala, UG · NCT07146048

  • Korea VHD Echo Study: Real-World Practice of Aortic, Mitral, and Tricuspid Valves

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  • Screening for Rheumatic Heart Disease in Rural Communities

    This study is testing if using ultrasound to screen for Rheumatic Heart Disease in rural communities can help find and treat the condition early to improve health outcomes.

    Recruiting National Institute of Cardiovascular Diseases, Pakistan · Karachi, Sindh · NCT05991219

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.