School-based program to prevent rheumatic heart disease in kids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses an incomplete stepped wedge cluster design to introduce a school-nurse program plus an awareness campaign for GABHS pharyngitis and secondary antibiotic prophylaxis. Clusters are whole schools in Kathmandu, Lusaka, and Mekelle, randomized to different start times so every school eventually receives the program. Each school will have one year in the control phase followed by a year in the intervention phase, with before-and-after measurements. The aim is to see if the program reduces progression risk and improves care for children with latent RHD in endemic settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 5-16 years
* Attending a randomly selected school at one of the three study sites

Exclusion Criteria:

* Children / primary caregivers not providing informed consent to participate.
* Children not attending one of the selected schools

Where it's running

• Kalingalinga
  Lusaka, Lusaka Province, Zambia Recruiting

Study contacts

• Study coordinator: Guy Kayeye Muula, MD, MPH
• Email: Guy.Muula@cidrz.org
• Phone: 0971747550

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Adapting and testing PEN-Plus in Zambian primary care

  Aiming to see if the PEN-Plus package can be adapted and used in two Zambian hospitals to better manage chronic diseases like heart disease, diabetes, hypertension, and sickle cell in primary care.

  Recruiting Centre for Infectious Disease Research in Zambia · Lusaka, Lusaka Province · NCT07753681

• Stop penicillin in children with mild rheumatic heart disease to see if it’s still safe

  This study tests whether stopping secondary antibiotic prophylaxis is no worse than continuing it for 2 years in kids and teens with mild rheumatic heart disease who have already been treated.

  Recruiting Phase 3 Children's Hospital Medical Center, Cincinnati · Kampala, UG · NCT07146048

• Korea VHD Echo Study: Real-World Practice of Aortic, Mitral, and Tricuspid Valves

  This study looks at how valvular heart disease is managed in Korea by reviewing echocardiograms and medical records from multiple centers to see patterns in disease progression and treatment.

  Recruiting at 2 sites Yonsei University · Seoul, Seoul and 1 other locations · NCT07068633

• Treating severe mitral valve calcification with a specialized balloon

  This study is testing a special balloon treatment for people with severe mitral valve calcification to see if it can help them feel better when other options aren't safe or effective.

  Recruiting Prince of Wales Hospital, Shatin, Hong Kong · Shatin, New Territories · NCT06952374

• Screening for Rheumatic Heart Disease in Rural Communities

  This study is testing if using ultrasound to screen for Rheumatic Heart Disease in rural communities can help find and treat the condition early to improve health outcomes.

  Recruiting National Institute of Cardiovascular Diseases, Pakistan · Karachi, Sindh · NCT05991219

• Program to prevent rheumatic heart disease in Northern Uganda

  This study is testing a new program in Northern Uganda to see if it can effectively prevent Rheumatic Heart Disease in children and young adults through community screenings and local health services.

  Recruiting Children's Hospital Medical Center, Cincinnati · Kampala, Uganda · NCT05783375

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.