Clinical trial Recruiting at 1 site Observational Ages 10 to 30

Screening for Rheumatic Heart Disease in Rural Communities

Official title: Screening and Secondary Prevention Rheumatic Heart Disease

Run by National Institute of Cardiovascular Diseases, Pakistan · NCT05991219 · Data updated 2026-11-12

This study is testing if using ultrasound to screen for Rheumatic Heart Disease in rural communities can help find and treat the condition early to improve health outcomes.

Quick facts

Study typeObservational
Ages10 Years to 30 Years
SexAll
Enrollment5000 (estimated)
SponsorNational Institute of Cardiovascular Diseases, Pakistan
Academic / other
Locations1 site (Karachi, Sindh)
StatusRecruiting
StartedSeptember 26, 2022
Main results expectedDecember 31, 2028
Study endsDecember 31, 2028
Registry record updatedAugust 15, 2023
Trial IDNCT05991219 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals living in rural communities in Sindh who are at risk for Rheumatic Heart Disease.

Probably not a fit

Patients who refuse to participate in the study will not receive any benefit from the interventions offered.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on screening for Rheumatic Heart Disease (RHD) in rural communities of Sindh using point of care ultrasound to assess heart valve conditions. Patients diagnosed with RHD will receive tailored treatment and referrals based on the severity of their condition. The study aims to implement community health worker-led antibiotic prophylaxis to prevent disease progression, with follow-up imaging scheduled at two and five years to evaluate outcomes. The goal is to identify and manage RHD early to improve patient outcomes in a cost-effective manner.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the progression of Rheumatic Heart Disease and improve long-term heart health for affected patients.

How similar studies have gone: Other studies have shown success in using point of care ultrasound for early detection and management of Rheumatic Heart Disease, indicating that this approach is promising.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Rural communities in Sindh

Exclusion Criteria:

* Refused to participate in the study

Where it's running

  • National Institute of Cardiovascular Diseases (NICVD)
    Karachi, Sindh, Pakistan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Program to prevent rheumatic heart disease in Northern Uganda

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.