Prognostic model for neurocritical patients using multimodal brain monitoring

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter observational cohort conducted in China, enrolling adults with acute brain injury such as large stroke, intracranial hemorrhage, subarachnoid hemorrhage, or severe traumatic brain injury. Researchers will collect multimodal brain monitoring data (EEG, transcranial Doppler, and near-infrared spectroscopy) within 1–3 days of ICU admission and apply machine learning to develop a prognostic model for 90-day outcomes. The primary aim is to categorize patients as awake, comatose, or deceased to support personalized treatment decisions. No experimental interventions are involved; the study only observes and analyzes data from standard monitoring. Eligible patients are 18–80 years old and require at least 72 hours of ICU monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 18-80 years, no gender restrictions.
2. Diagnosed with acute brain injury (ABI), including one of the following: large cerebral infarction, supratentorial large-volume intracerebral hemorrhage, subarachnoid hemorrhage, or severe traumatic brain injury, with imaging evidence (CT or MRI) supporting the diagnosis.
3. On ICU admission, Glasgow Coma Scale (GCS) eye response = 1 (no eye opening) and motor score ≤ 5 (does not follow commands); or within 48 hours, neurological deterioration with no eye opening and motor score reduced to ≤ 5 (total GCS score ≤ 8).
4. Able to undergo continuous multimodal monitoring, with an expected ICU stay of ≥72 hours.
5. Informed consent signed by the family or legal representative.

Exclusion Criteria:

1. Confirmed brain death on admission or imaging showing irreversible brain herniation.
2. Severe trauma unrelated to brain injury (e.g., multiple fractures, spinal cord injuries, or visceral rupture) that may interfere with brain function monitoring or outcome assessment.
3. Pre-existing severe neurological disorders such as epilepsy, severe encephalopathy, or chronic intracranial conditions (e.g., brain tumors or hydrocephalus).
4. Inability to perform multimodal monitoring due to technical issues (e.g., equipment failure or sensor installation problems).
5. Predicted survival time \<24 hours after admission, or family members choose to withdraw treatment.
6. Refusal to participate in the study by the patient or their legal representative.

Where it's running

• XiangyaHospital of Central South University
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Zhang
• Email: zlzdzlzd@csu.edu.cn
• Phone: +86 731 8975 3999

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.