Proactive risk-based coordination to shorten time from surgery to post-operative radiation for head and neck cancer
Official title: Proactive Risk-based Optimization & Notifications for Treatment & Outcomes (PRONTO) in Head & Neck Cancer: A Strategy to Reduce Delays From Surgery to Post-Operative Adjuvant Therapy in Head and Neck Cancer
Run by Centre hospitalier de l'Université de Montréal (CHUM) · NCT07180901 · Data updated 2026-11-12
This pilot tests whether an automated care-coordination system (PRONTO-HN) can help adults with oral or laryngeal squamous cell carcinoma begin post-operative radiotherapy within 42 days after surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 85 (estimated) |
| Sponsor | Centre hospitalier de l'Université de Montréal (CHUM) Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Status | Recruiting |
| Started | August 21, 2025 |
| Main results expected | October 21, 2026 |
| Study ends | October 21, 2029 |
| Registry record updated | September 18, 2025 |
| Trial ID | NCT07180901 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with pathologically confirmed oral cavity or laryngeal squamous cell carcinoma who are planned for primary surgical resection and receive care at CHUM between July 2024 and September 2026 are eligible.
✕Probably not a fit
Patients who do not undergo surgery, those with S-PORT delays beyond 180 days, or patients treated outside CHUM are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center, quasi-experimental interrupted time-series pilot compares a historical control period (August 2024–August 2025) with an intervention period (September 2025–September 2026) at the Centre hospitalier de l'Université de Montréal (CHUM). The intervention, PRONTO-HN, delivers automated alerts, multidisciplinary task coordination, and risk stratification using a predictive model built from pre-operative data. The primary focus is improving adherence to recommended surgery-to-post-operative-radiotherapy (S-PORT) intervals of ≤42 days. Outcomes will compare the proportion of patients meeting the S-PORT target before and after implementation and examine process measures related to scheduling and coordination.
Why it matters
Potential benefit: If successful, PRONTO-HN could increase the number of patients starting post-operative radiotherapy within recommended timelines, which is associated with better oncologic outcomes.
How similar studies have gone: Observational research consistently links shorter S-PORT intervals to better outcomes, but automated, risk-based coordination systems like PRONTO-HN are novel and have limited prior interventional evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients (age 18 or older). * Pathologically confirmed oral cavity or laryngeal squamous cell carcinoma. * Diagnosed from July 2024 to September 2026. * With planned primary intention surgical resection. * With or without adjuvant therapy. * Treated at the Centre Hospitalier de l'Université de Montréal. Exclusion Criteria: * Patients who do not end up receiving surgery. * S-PORT \> 180 days
Where it's running
-
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada Recruiting
Study contacts
- Principal investigator: Houda Bahig, MD PhD — Centre hospitalier de l'Université de Montréal (CHUM)
- Study coordinator: Apostolos Christopoulos, MD, MSc
- Email: a.christopoulos@umontreal.ca
- Phone: +1 (514) 625-7360
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.