Pressure-controlled volume-guided vs volume-controlled ventilation during laparoscopic abdominal cancer surgery
Official title: Effect of Pressure-Controlled Volume Guaranteed Versus Volume-Controlled Ventilation Modes on Hemodynamic Outcomes and Respiratory Mechanics During Laparoscopic Abdominal Cancer Surgeries With Exaggerated Trendelenberg Postion : A Randomized Controlled Trial
Run by Assiut University · NCT07550738 · Data updated 2026-11-12
This study tests whether two ventilation modes—PC-VG and VCV—affect heart and lung function in adults undergoing laparoscopic abdominal cancer surgery with a tilted position.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | July 2, 2026 |
| Trial ID | NCT07550738 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 20–80 years with ASA I–II undergoing elective laparoscopic abdominal cancer surgery, without severe cardiopulmonary or neuromuscular disease or obesity (BMI ≤ 30).
✕Probably not a fit
Patients with severe systemic disease, COPD/restrictive lung disease, obesity (BMI > 30), or neurologic neuromuscular conditions may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial compares two ventilation strategies in adults scheduled for elective laparoscopic abdominal cancer surgery with exaggerated Trendelenberg position. Primary outcomes focus on hemodynamics such as stroke volume, cardiac output, and cardiac index measured with ICON cardio-tonic technology. Secondary outcomes look at respiratory effects including atelectasis, plateau pressure, peak inspiratory pressure, dynamic compliance, and postoperative inflammatory markers like CRP and WBCs. Lung ultrasound and electrical cardiometry are used to monitor respiratory and cardiovascular status during the procedure. The study is conducted at Assiut University and South Egypt Cancer Institute in Egypt, involving adults aged 20 to 80 with ASA I-II, excluding those with significant cardiopulmonary disease or obesity.
Why it matters
Potential benefit: If successful, this approach could help tailor ventilation to improve heart and lung function during complex abdominal cancer surgeries.
How similar studies have gone: Previous research has explored ventilation modes and hemodynamics, but this study uses a specific combination with exaggerated Trendelenberg position and dual monitoring to clarify effects.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1 - All patients who will be scheduled for elective laparoscopic abdominal cancer surgeries 2- patients aged 20-80 years 3- patients have an American Society of Anesthesiologists (ASA) physical status I-II Exclusion Criteria: 1 - Patients with severe systemic disease (history of myocardial infarction, chronic obstructive, or restrictive lung disease) 2- Obese patients (BMI \> 30) 3- patients with neurologic or neuromuscular diseases.
Where it's running
-
South Egypt cancer institute , Assiut university
Asyut, Egypt Recruiting
Study contacts
- Study coordinator: Saif eldeen Gamal Khalaf, Assistant lecturer
- Email: saifeldeen616@gmail.com
- Phone: +20-1033893202
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.