Lower-dose induction for pediatric AML with G-CSF support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial investigates a low-dose induction approach using Ara-C and an anthracycline in combination with G-CSF for pediatric patients with de novo AML. It aims to reduce treatment-related morbidity and mortality that are common during induction, especially in resource-limited settings, while maintaining effectiveness. The regimen reflects a balance between minimizing toxicity and preserving the chance of remission, with standard consolidation therapy following induction as appropriate. Enrollment targets pediatric patients under 18 without promyelocytic leukemia, Down syndrome-associated AML under age 4, AML secondary to prior conditions, or prior treatment-related death before initiation. The lead sponsor is Azza Shibl Sayed, with sites in South Egypt at Assiut University and South Egypt Cancer Institute in Assiut, Egypt.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Denovo pediatric AML patients.
* equal or \<18 years old

Exclusion Criteria:

* Children with promyelocytic leukemia
* Down syndrome with AML with age less than 4 years.
* AML secondary to myelodysplastic syndrome or prior chemotherapy.
* death before treatment initiation

Where it's running

• South Egypt Cancer Institute, Assiut Univeristy
  Asyut, Asyut Governorate, Egypt Recruiting
• South Egypt Cancer Institute, Assiut Univeristy
  Asyut, Asyut Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Azza Shibl, MD
• Email: azzashibl@aun.edu.eg
• Phone: 00201021880322

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.