Oral Gabapentin vs IV Neostigmine/Atropine vs Both for Preventing PDPH

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares three approaches to prevent postdural puncture headache (PDPH) following spinal anesthesia for cesarean delivery: oral gabapentin, intravenous neostigmine with atropine, and a combination of both. It targets pregnant women with a single full-term fetus and BMI 25–35, across Phase 2 and Phase 3. Outcomes focus on the incidence and severity of PDPH, plus safety and tolerability of the regimens. The study reflects existing literature on pharmacologic prophylaxis for PDPH and explores whether a combination strategy offers added benefit. Conducted at Assiut University Hospital, the trial is sponsored by Assiut University with no listed collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Scheduled for elective CS under spinal anesthesia.
* BMI between 25 and 35 kg/m2.
* ASA 11 primigravida or multigravida.
* Pregnant in a single full-term fetus.

Exclusion Criteria:

* Emergency CS.
* Chronic headache or previous PDPH.
* Any type of chronic pain and those on regular analgesics or anti-epileptic medications.
* Substance abuse.
* Smoking.
* Chronic or gestational hypertension.
* hypersensitivity to one of the used drugs.
* liver, kidney, neurological and psychiatric disorders.
* patient refusal

Where it's running

• Assiut University hospital
  Asyut, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.