Change in Fat Content of Bone Metastases After Treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses non-contrast Dixon MRI to measure how fat content in lytic bone metastases changes from before to after cancer treatment. By comparing fat fraction in the lesion to normal marrow, researchers aim to detect early treatment response without radiation exposure. Participants are adults with solid tumors and at least one lytic bone metastasis who are about to receive chemotherapy or radiotherapy. The largest eligible lesion will be analyzed, and follow-up MRI will occur after treatment completion. The goal is to determine whether Dixon MRI can provide earlier, radiation-free indications of response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Solid-tumor malignancy with ≥1 lytic bone metastasis (≥1 cm) confirmed on CT. (When a patient has more than one qualifying lytic lesion, the largest and/or most accessible lesion (whichever allows more reliable, artifact-free ROI placement) will be selected for analysis.)
* Scheduled for chemotherapy or radiotherapy to the involved region.
* Age ≥18, able to undergo MRI,
* Informed consent given.

Exclusion Criteria:

* Sclerotic/mixed lesions.
* Prior focal treatment to the lesion.
* Pathological fracture at the site.
* Patients receiving concurrent bone-targeting therapy (bisphosphonates or denosumab) during the study period, as these independently alter marrow fat content.
* MRI contraindications.
* Inability to complete follow-up scan.

Where it's running

• South Egypt Cancer Institute, Assiut University
  Asyut, Assiut Governate, Egypt Recruiting

Study contacts

• Study coordinator: Ibrahem Abdelnaser Zohry, MBBCh
• Email: ibrahim.18313355@med.aun.edu.eg
• Phone: +201555433075

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.