Prehabilitation program for liver transplant patients
Does a Multimodal Prehabilitation Program Improve Markers of Frailty in Patients With Cirrhosis Undergoing Liver Transplantation? A Feasibility Trial
NA · McGill University Health Centre/Research Institute of the McGill University Health Centre · NCT05237583
This study tests a prehabilitation program that helps liver transplant patients get stronger and healthier before surgery to see if it can improve their recovery and reduce complications.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre (other) |
| Locations | 1 site (Montréal, Quebec) |
| Trial ID | NCT05237583 on ClinicalTrials.gov |
What this trial studies
This study assesses the feasibility, safety, and effectiveness of a structured prehabilitation program for patients with cirrhosis awaiting liver transplantation. The program combines exercise training, nutritional optimization, and psychological support to improve muscle mass, nutritional status, and overall tolerance to exercise. By addressing these factors, the study aims to reduce postoperative complications and improve recovery outcomes for patients undergoing major surgery. Participants will receive individualized support tailored to their specific needs.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old diagnosed with cirrhosis who are actively on the liver transplant waiting list.
Not a fit: Patients with severe liver disease complications or conditions that limit their ability to exercise may not benefit from this program.
Why it matters
Potential benefit: If successful, this program could significantly enhance recovery and reduce complications for patients undergoing liver transplantation.
How similar studies have performed: Other studies have shown promising results with prehabilitation approaches in surgical patients, suggesting potential success for this program.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age above 18 years * Diagnosis of cirrhosis, based on a combination of clinical, laboratory, imaging, or histology * Active on the liver transplant waiting list of the MUHC Exclusion Criteria: * Biological Model for End Stage Liver Disease \>20 * Hepatic decompensation within the last month * High risk varices not on primary or secondary prevention * Recurrent large volume paracentesis * Persistent hepatic encephalopathy * Platelets \<20,000/µL, or hemoglobin \<80g/L * Altered hemodynamics * Significant heart disease * Awaiting combined organ transplantation * Awaiting repeat liver transplantation * Condition limiting mobilization and/or exercise, or recurrent falls
Where this trial is running
Montréal, Quebec
- McGill University Health Centre — Montréal, Quebec, Canada (RECRUITING)
Study contacts
- Principal investigator: Amine Benmassaoud, MD — Research Institute of the McGill University Health Centre
- Study coordinator: Amine Benmassaoud, MD
- Email: amine.benmassaoud@mcgill.ca
- Phone: 5149341934
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cirrhosis, Liver, Liver Transplantation, Frailty, Prehabilitation, Nutrition, Quality of life, Exercise, Cirrhosis