Cardiac rehab in CAD: does it affect ferroptosis?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study enrolls 90 participants divided into three groups: CAD patients in a cardiac rehabilitation program, CAD patients who do not participate, and healthy controls. It will compare ferroptosis-related biomarkers among the groups to see if exercise-based rehab influences iron-dependent cell death pathways in CAD. Participants will undergo cardiopulmonary testing and blood sampling to assess biomarkers before and after the rehabilitation period. The trial is conducted at Erciyes University, examining feasibility and biological signals that could link rehab with ferroptosis in CAD. The design is interventional with a comparative, observational component for healthy controls.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients With Coronary Artery Disease (CAD):

* Age between 18 and 75 years.
* Diagnosis of coronary artery disease within the previous 3 months.
* Eligible to participate in a cardiac rehabilitation program or voluntarily decline participation in the cardiac rehabilitation program.
* Peak exercise capacity of ≥5 metabolic equivalents (METs).
* Able to undergo cardiopulmonary exercise testing (CPET).
* Able to understand the study procedures and provide written informed consent.

Healthy Controls:

* Age between 18 and 75 years.
* No history of coronary artery disease or other cardiovascular diseases.
* No history of chronic systemic diseases, including diabetes mellitus, hypertension, chronic kidney disease, chronic liver disease, inflammatory or autoimmune diseases, or malignancy.
* Not receiving regular medication.
* Able to provide written informed consent.

Exclusion Criteria:

Patients With Coronary Artery Disease (CAD):

* Decompensated heart failure.
* Unstable angina pectoris.
* Uncontrolled or complex ventricular arrhythmias.
* Severe pulmonary hypertension.
* Neurological, orthopedic, or musculoskeletal disorders limiting exercise performance.
* Absolute contraindications to cardiopulmonary exercise testing or cardiac rehabilitation according to current clinical guidelines.
* Chronic kidney failure or chronic liver disease.
* Active infection.
* Active inflammatory or autoimmune disease.
* Active malignancy or history of malignancy.
* Pregnancy.
* Cognitive or psychiatric disorders that would interfere with study participation or protocol compliance.

Healthy Controls:

* History of coronary artery disease or other cardiovascular diseases.
* History of chronic systemic diseases, including diabetes mellitus, hypertension, chronic kidney disease, chronic liver disease, inflammatory or autoimmune diseases, or malignancy.
* Regular medication use within the previous 6 months.
* Active infection.
* Pregnancy.
* Age younger than 18 years or older than 75 years.

Where it's running

• Erciyes University Faculty of Medicine
  Kayseri, Kayseri, Turkey (Türkiye) Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.