Predicting brain swelling after stroke treatment
Official title: Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study)
Run by Zhejiang Provincial People's Hospital · NCT06451887 · Data updated 2026-11-12
This study is testing a new way to predict which stroke patients are at risk for dangerous brain swelling after a specific treatment to help doctors make better decisions for their care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 1950 (estimated) |
| Sponsor | Zhejiang Provincial People's Hospital Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Status | Recruiting |
| Started | April 1, 2024 |
| Main results expected | March 2027 |
| Study ends | June 2027 |
| Registry record updated | June 11, 2024 |
| Trial ID | NCT06451887 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old who have experienced an ischemic stroke and are undergoing endovascular thrombectomy within 24 hours of symptom onset.
✕Probably not a fit
Patients with posterior circulation occlusion or those with severe comorbidities that limit their expected survival may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to design and validate a predictive model for malignant brain edema (MBE) following endovascular thrombectomy (EVT) in patients with acute large vessel occlusion stroke. By identifying high-risk patients for MBE, clinicians can make informed decisions regarding triage and early interventions, potentially improving patient outcomes. The study will analyze various predictive factors, including clinical and radiological indicators, to enhance the accuracy of early predictions for MBE. The ultimate goal is to reduce morbidity and mortality associated with this severe complication of stroke treatment.
Why it matters
Potential benefit: If successful, this study could lead to improved patient outcomes by enabling timely interventions for those at high risk of malignant brain edema.
How similar studies have gone: Previous studies have shown promise in identifying predictive factors for malignant brain edema, suggesting that this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * (1)Age \> 18 years old; (2)Onset of stroke to hospital admission \< 24 hours; (3)Admission with a head CT scan ruling out hemorrhage; (4)Patients undergoing CT perfusion scan before treatment; (5)Confirmation of internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion or tandem occlusion by Digital Subtraction Angiography (DSA) and subsequent EVT; (6)complete 3-months follow-up. Exclusion Criteria: * (1)Poor quality of preoperative CT perfusion imaging; (2)Posterior circulation occlusion or isolated anterior cerebral artery occlusion; (3)Presence of other severe diseases such as malignant tumors, severe organ failure, or other life-threatening conditions with an expected survival period of less than 90 days; (4)Incomplete imaging and clinical data.
Where it's running
-
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Study coordinator: Sheng Zhang
- Email: zhangsheng@hmc.edu.cn
- Phone: 18758188313
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.