Precision brain mapping to guide neuromodulation after spontaneous intracerebral hemorrhage
Official title: PREcision MApping and NEuromodulation After Spontaneous Intracerebral Hemorrhage: The PREMANE Trial
Run by National University Hospital, Singapore · NCT07908264 · Data updated 2026-11-12
This trial tests whether personalized transcranial magnetic stimulation targets, identified with individual brain maps, help improve motor and cognitive functions after spontaneous ICH.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 65 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | National University Hospital, Singapore Academic / other |
| Locations | 2 sites (Singapore and 1 other locations) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | November 2, 2026 |
| Trial ID | NCT07908264 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 21–65 with radiologically confirmed spontaneous intracerebral hemorrhage, able to communicate in English, and with relatively preserved baseline motor function (FMA-UE score ≤ 46 and MoCA ≤ 25).
✕Probably not a fit
Patients with non-spontaneous hemorrhage, severe cognitive impairment beyond the inclusion thresholds, or contraindications to TMS may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized cross-over pilot study investigates whether active transcranial magnetic stimulation (TMS) targeted to individually mapped brain networks can improve recovery after spontaneous intracerebral hemorrhage. Participants receive either sham TMS first or active TMS first for one week, followed by a three-week washout and crossover to the other arm, while all receive standard rehabilitation. Primary outcomes include motor function, language, and cognitive measures, with assessments at multiple timepoints up to one year. Secondary outcomes examine changes in brain network connectivity using precision functional mapping. The study uses blinded participants, investigators, technicians, and outcome assessors to reduce bias.
Why it matters
Potential benefit: If successful, participants may experience greater improvements in motor and cognitive abilities after ICH through personalized neuromodulation.
How similar studies have gone: Prior stroke neuromodulation trials suggest potential benefits of targeted TMS, but this approach using individualized network maps is novel and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Aged 21 to 65 years old. 2. A radiologically confirmed diagnosis of SICH on baseline CT-imaging 3. Able to communicate in English (including patients with dysphasia and those who are unable to write) Exclusion Criteria: * Patients with hemorrhage related to trauma, tumor, ischemic stroke, vascular malformations, and other structural causes * Prior cognitive impairments * Pregnant women * Foreigners * FMA-UE score \> 46 * MoCA score \> 25 * Patients with history of seizures or an epileptic * Patients who have been diagnosed with or have a history of mental health conditions (any psychological disorders)
Where it's running
-
Alexandra Hospital
Singapore, Singapore Recruiting -
National University Hospital
Singapore, Singapore Recruiting
Study contacts
- Principal investigator: Mervyn JR Lim — National University Hospital, Singapore
- Study coordinator: Mervyn JR Lim
- Email: mervynlim@u.nus.edu
- Phone: +65 6908 2222
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.