Oral vs IV Magnesium for Emergence Delirium in Children after Adenotonsillectomy
Official title: Effect of Oral Versus Intravenous Magnesium on Emergence Delirium in Children Undergoing Adenotonsillectomy: A Two-Center, Randomized, Double-Blind, Placebo-Controlled Study
Run by Tanta University · NCT07655817 · Data updated 2026-11-12
This trial tests whether giving magnesium by mouth before surgery or by IV during surgery can reduce emergence delirium in children aged 4–7 undergoing adenotonsillectomy with sevoflurane anesthesia.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 4 Years to 7 Years |
| Sex | All |
| Enrollment | 360 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, Gharbia Governorate) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | December 24, 2026 |
| Study ends | December 25, 2026 |
| Registry record updated | July 6, 2026 |
| Trial ID | NCT07655817 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 4 to 7 years with ASA I–II status scheduled for adenotonsillectomy under sevoflurane anesthesia.
✕Probably not a fit
Children with behavioral, neurological, or psychiatric conditions, anticonvulsant or sedative use, or magnesium allergies may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, controlled study comparing two magnesium delivery methods in children undergoing adenotonsillectomy under sevoflurane anesthesia. It aims to see if preoperative oral magnesium or intraoperative IV magnesium lowers the occurrence and severity of emergence delirium. Magnesium is explored for its potential anesthetic- and analgesic-sparing effects and calming properties. The study builds on mixed prior results for IV magnesium and seeks to determine if oral magnesium before induction offers additional benefit. Participants will be ASA I–II and 4–7 years old, with outcomes focused on delirium incidence and severity.
Why it matters
Potential benefit: If successful, the approach could reduce emergence delirium and improve recovery experiences for children undergoing adenotonsillectomy.
How similar studies have gone: Previous studies on IV magnesium have shown inconsistent results; this trial investigates whether alternative timing or route (oral) may provide clearer benefits.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children aged 4 to 7 years * American Society of Anesthesiologist (ASA) Status I or II * Planned for an adenotonsillectomy procedure under sevoflurane general anesthesia. Exclusion Criteria: * Parents declined to participate in the trial * Behavioral changes, neurological or psychiatric problems * Anticonvulsant or sedative drugs * Physical or developmental abnormalities * Allergies to magnesium * cardiovascular, renal, bone, or gastrointestinal diseases.
Where it's running
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Tanta University Hospitals
Tanta, Gharbia Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Osama M Rehab, MD
- Email: osamarehab@med.tanta.edu.eg
- Phone: +201095210806
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy
This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.
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Lactium premedication to see if it prevents emergence agitation after adenotonsillectomy
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Live parent-child video interaction or cartoon watching to ease emergence agitation in preschoolers
This study tests whether live video calls with a parent or watching cartoons during preoperative transfer can reduce anxiety before anesthesia and agitation after surgery in 2- to 6-year-olds undergoing elective procedures.
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Postoperative Pain After Pediatric Adenotonsillectomy: Ibuprofen Plus Tylenol vs Ketorolac Plus Tylenol
This observational study will see if teens (13-18) who have adenotonsillectomy and take acetaminophen with ibuprofen or acetaminophen with ketorolac after discharge experience different levels of pain and recovery.
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A nightly magnesium and melatonin supplement is being tested to see if it improves sleep quality in adults with nighttime leg cramps.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.