Ultrasound-guided glossopharyngeal and maxillary nerve blocks for pain control after adenotonsillectomy
Official title: Ultrasound Guided Glossopharyngeal and Maxillary Nerve Blocks for Perioperative Pain Control in Adenotonsillectomy in Pediatrics: A Randomized Controlled Trial.
Run by Cairo University · NCT07379866 · Data updated 2026-11-12
Doctors will test whether adding ultrasound-guided glossopharyngeal and maxillary nerve blocks to usual pain control reduces pain after adenotonsillectomy in children aged 5–13.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 5 Years to 13 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo, Governorate) |
| Status | Recruiting |
| Started | January 2026 |
| Main results expected | May 2026 |
| Study ends | June 2026 |
| Registry record updated | February 2, 2026 |
| Trial ID | NCT07379866 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children aged 5–13 years with ASA physical status I–II who are scheduled for adenotonsillectomy and have no contraindication to local anesthetics or nerve block procedures.
✕Probably not a fit
Children who are ASA class III–IV, morbidly obese, have infection at the injection site, recent upper respiratory infection, allergy to local anesthetics, developmental delays, recent regular analgesic use, or whose parents refuse participation are not eligible and would not receive benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional study enrolls pediatric patients aged 5 to 13 undergoing adenotonsillectomy at Cairo University Hospitals. After standard premedication and induction of general anesthesia, participants are randomized to receive combined bilateral ultrasound-guided glossopharyngeal and maxillary nerve blocks plus standard multimodal analgesia or to receive standard multimodal analgesia alone (placebo block group). Standard intraoperative monitoring, IV analgesics including paracetamol, and anesthetic techniques are used for all patients. Outcomes focus on postoperative pain control and analgesic requirements following the operation.
Why it matters
Potential benefit: If successful, the nerve-block approach could lower postoperative pain and reduce the need for systemic opioids in children after adenotonsillectomy.
How similar studies have gone: Previous studies of regional nerve blocks for tonsillectomy have reported reduced postoperative pain and opioid use, though combined ultrasound-guided glossopharyngeal plus maxillary blocks are less extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pediatric patients aged 5 to 13 years * American Society of Anesthesiologists (ASA) physical status I-II scheduled for adenotonsillectomy. Exclusion Criteria: * Parents Refusal * Cognitive impairment or developmental delays. * Infection at injection site. * Recent upper respiratory tract infection. * Post-tonsillectomy bleeding, allergy to local anesthetics. * American Society of Anesthesiologists (ASA) class III and IV. * Morbid obesity. * Those receiving regular analgesia within the last week before surgery.
Where it's running
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Cairo University Hospitals
Cairo, Governorate, Egypt Recruiting
Study contacts
- Principal investigator: Nagy malak, MD — Cairo University
- Study coordinator: Nagy Malak, MD
- Email: nagymalak12345@gmail.com
- Phone: +201552480258
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy
This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.
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Lactium premedication to see if it prevents emergence agitation after adenotonsillectomy
A preoperative dose of Lactium is tested to see if it prevents emergence agitation in children after adenotonsillectomy.
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Postoperative Pain After Pediatric Adenotonsillectomy: Ibuprofen Plus Tylenol vs Ketorolac Plus Tylenol
This observational study will see if teens (13-18) who have adenotonsillectomy and take acetaminophen with ibuprofen or acetaminophen with ketorolac after discharge experience different levels of pain and recovery.
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Oral vs IV Magnesium for Emergence Delirium in Children after Adenotonsillectomy
This trial tests whether giving magnesium by mouth before surgery or by IV during surgery can reduce emergence delirium in children aged 4–7 undergoing adenotonsillectomy with sevoflurane anesthesia.
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Intranasal dexmedetomidine‑esketamine for pain relief after adenoid and tonsil surgery in children
This trial will test whether giving children aged 3–7 a combined dexmedetomidine and esketamine nasal dose reduces pain after adenoid and tonsil surgery.
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Oral melatonin versus nebulized dexmedetomidine to reduce emergence agitation after adenotonsillectomy in children
We will test whether giving oral melatonin or nebulized dexmedetomidine before anesthesia better prevents children aged 3–7 from becoming agitated as they wake after adenotonsillectomy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.