Postoperative Lung Function Prediction in Lung Cancer Patients
Official title: Post-Operative Prediction of PulmonarY Function A Pilot Study to Assess the Benefit of Incorporating Regional Ventilation Information in the Prediction of Post-operative Lung Function for Lung Cancer Surgery
Run by University of Sydney · NCT06494254 · Data updated 2026-11-12
This study compares CT ventilation imaging-based predictions of postoperative lung function with the standard anatomically based method in adults with lung cancer undergoing evaluation for surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | University of Sydney Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Saint Leonards, New South Wales) |
| Status | Recruiting |
| Started | June 25, 2025 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | May 20, 2026 |
| Trial ID | NCT06494254 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with lung cancer who are surgical candidates, have ECOG 0-2, and can undergo SPECT V/Q, BHCT, and PFT testing within eight weeks of registration.
✕Probably not a fit
Patients without significant regional lung function differences or those not undergoing surgery may have limited benefit from this imaging approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to see if CT ventilation imaging can more accurately predict postoperative lung function than the traditional anatomical segment counting method. It will analyze predicted postoperative values such as FEV1 and DLCO in patients with non-small cell lung cancer who are candidates for surgical resection. Participants undergo SPECT V/Q scans, BHCT scans, and pulmonary function tests within eight weeks of enrollment to compare methods. The goal is to determine whether regional lung function information from CT ventilation imaging improves risk stratification for surgical planning. Results could influence preoperative assessment workflows and access to less invasive imaging options.
Why it matters
Potential benefit: If CT ventilation imaging proves more accurate, patients may receive better risk estimates before surgery, potentially guiding treatment choices and improving safety.
How similar studies have gone: Previous work suggests regional imaging can refine risk assessment, but this specific comparative approach with CT ventilation imaging is relatively novel in preoperative planning.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years or older. * ECOG performance status 0-2. * Lung cancer surgical candidates. * Undergo SPECT V/Q scans within 8 weeks of registration. * Undergo BHCT scans within 8 weeks of registration. * Pulmonary function tests within 8 weeks of registration. * Willingness to give written informed consent. * Willingness and ability to comply with the study procedures and visit requirements. Exclusion Criteria: * Interstitial lung disease. * Pregnant women.
Where it's running
-
Royal North Shore Hospital
Saint Leonards, New South Wales, Australia Recruiting
Study contacts
- Principal investigator: Dasantha Jayamanne, Dr — University of Sydney
- Study coordinator: Clinical Trial Coordinator
- Email: shona.silvester@sydney.edu.au
- Phone: +61 2 8627 1185
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.