Postoperative High-Flow Oxygen After High-Risk Abdominal and Non-Cardiac Thoracic Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares high-flow nasal oxygen (HFNO) with conventional oxygen therapy (COT) in adults undergoing high-risk elective abdominal or non-cardiac thoracic surgery lasting more than three hours. Eligible participants are 18 or older and meet at least two high-risk criteria such as age over 65, BMI over 30, or recent respiratory issues, among others. The goal is to see if HFNO reduces postoperative pulmonary complications, hypoxaemia, and need for escalation of therapy compared with COT. The trial is led by Region Stockholm with Karolinska Institutet and conducted at Karolinska University Hospital in Stockholm. Details on endpoints and exact methods are not provided in the summary.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults (≥18 years old) scheduled for elective abdominal (laparotomy or laparoscopy), open abdominal vascular or non-cardiac thoracic surgery under general anaesthesia with an estimated duration over 3 hours.

AND

Meeting at least two of the following criteria:

* Age \> 65 years
* BMI \>30
* Preoperative SpO2 \<95 %
* Scheduled for lobectomy or pulmonary segment resection
* Respiratory tract infection the last month
* Preoperative anaemia (Hb \<100) or severe hypoalbuminemia (\<20 g/L)
* Current smoker or previous smoker with \>30 packyears
* Pulmonary disease or OSAS
* Heart failure
* Clinical frailty (CFS 4)

Exclusion Criteria:

* Not suitable for postoperative HFNO, as decided by a study member or the anaesthetist in charge (such as total nasal obstruction, skull fracture, facial injuries)
* Pregnancy
* Not able to understand the study information or sign an informed consent.
* Not able to participate with the treatment postoperatively
* Planned for delayed extubation in the intensive care
* Preoperative non-invasive ventilation due to respiratory failure or a higher level of care than a regular ward

Where it's running

• Karolinska University Hospital
  Stockholm, Sweden Recruiting

Study contacts

• Study coordinator: Ida-Maria Forsberg, PhD
• Email: ida-maria.forsberg@regionstockholm.se
• Phone: +46704381445

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.