Automated lung recruitment during major laparoscopic colorectal cancer surgery
Effect of Automated Intraoperative Lung Recruitment Maneuvers on Atelectasis in Patients Undergoing Major Laparoscopic Surgery: A Randomized Controlled Trial
We will test whether automated ventilator lung recruitment during major laparoscopic colorectal cancer surgery reduces intraoperative atelectasis in adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 56 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Bakirkoy Dr. Sadi Konuk Research and Training Hospital Government |
| Drugs / interventions | radiation |
| Locations | 1 site (Istanbul, Bakırkoy) |
| Trial ID | NCT07349784 on ClinicalTrials.gov |
What this trial studies
This is a prospective, randomized, single-center trial comparing automated intraoperative lung recruitment maneuvers delivered by modern anesthesia ventilators with standard mechanical ventilation in adults undergoing elective major laparoscopic colorectal cancer surgery. Patients aged 18–80 with ASA physical status I–III will be randomized 1:1 after arrival in the operating room to receive either programmed automated recruitment maneuvers or standard ventilation without recruitment. Lung ultrasonography will be used at predefined perioperative time points to quantify atelectasis using a lung ultrasound score, and postoperative pulmonary complications and hemodynamic events will be recorded. Key exclusions include severe COPD, BMI>40 kg/m², advanced heart failure, prior thoracic surgery, preoperative oxygen requirement, conversion to open surgery, or significant hemodynamic instability during maneuvers.
Who should consider this trial
Good fit: Adults aged 18–80 scheduled for elective major laparoscopic colorectal cancer surgery with ASA I–III and without severe COPD, extreme obesity, or preoperative oxygen requirements are ideal candidates.
Not a fit: Patients with severe COPD (GOLD III–IV), advanced heart failure (LVEF <35%), BMI >40, prior thoracic surgery, those converted to open surgery, or who develop significant hemodynamic instability during recruitment are unlikely to receive benefit from the intervention.
Why it matters
Potential benefit: If successful, automated recruitment could standardized intraoperative lung inflation to reduce atelectasis and lower postoperative pulmonary complications after laparoscopic colorectal surgery.
How similar studies have performed: Manual lung recruitment maneuvers have shown mixed clinical benefits in prior perioperative studies, while automated ventilator-driven recruitment is less well studied but has produced promising physiological improvements in small trials.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 80 years * Scheduled for elective laparoscopic colorectal cancer surgery * American Society of Anesthesiologists (ASA) physical status I-III Exclusion Criteria: * ASA physical status IV or higher * Pregnancy * Body mass index (BMI) \> 40 kg/m² * Severe chronic obstructive pulmonary disease (COPD), GOLD stage III-IV * Advanced heart failure with left ventricular ejection fraction \<35% * Previous thoracic surgery * Preoperative requirement for supplemental oxygen therapy * Refusal or inability to provide informed consent * Intraoperative conversion to open surgery * Development of significant hemodynamic instability during lung recruitment maneuvers
Where this trial is running
Istanbul, Bakırkoy
- SBÜ Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi — Istanbul, Bakırkoy, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Sena Gökçe Karataş
- Email: senagokce_96@outlook.com
- Phone: +90 212 414 71 71
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.