Personalized pain management after thoracic surgery
Official title: Pharmacogenetics and Pharmacokinetics of Oxycodone to Personalize Postoperative Pain Management Following Thoracic Surgery in Adults
Run by OpalGenix, Inc · NCT05525923 · Data updated 2026-11-12
This study is testing a new way to manage pain after lung surgery to see if personalized plans can help patients feel better and use fewer opioids.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | OpalGenix, Inc Industry-sponsored |
| Locations | 4 sites (Pittsburgh, Pennsylvania and 3 other locations) |
| Status | Recruiting |
| Started | November 30, 2023 |
| Main results expected | March 1, 2026 |
| Study ends | March 1, 2028 |
| Registry record updated | May 1, 2025 |
| Trial ID | NCT05525923 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old, classified as ASA Physical Status 1, 2, or 3, who are scheduled for thoracic surgery.
✕Probably not a fit
Patients who are under 18, pregnant, have significant comorbidities, or are undergoing outpatient surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research focuses on improving postoperative pain management for adults undergoing thoracic surgery, specifically pneumonectomy, lobectomy, and segmentectomy. It aims to develop personalized risk prediction algorithms to enhance pain relief and reduce opioid use by comparing actual clinical outcomes with predicted outcomes based on individual risk assessments. The study addresses the significant challenges of severe post-surgical pain and the associated risks of opioid use, including chronic pain and opioid dependence. By tailoring pain management strategies, the study seeks to improve recovery and minimize adverse effects.
Why it matters
Potential benefit: If successful, this approach could lead to more effective pain management and reduced opioid-related complications for patients after thoracic surgery.
How similar studies have gone: Other studies have shown promise in personalized pain management approaches, but this specific methodology is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years * American Society of Anesthesiologists (ASA) Physical Status 1, 2, 3 * Undergoing thoracic surgery (TS; pneumonectomy, lobectomy and segmentectomy) Exclusion Criteria: * Children (\<18 years) * Pregnant women * American Society of Anesthesiologists (ASA) Physical Status 4 or above * Non-English speaking * Outpatient surgery * Concomitant additional surgical procedures * Significant liver and kidney dysfunction * Significant cardiorespiratory compromise * Patients with polysubstance use (e.g., cocaine, marijuana, amphetamine, etc.)
Where it's running
-
UPMC Presbyterian Hospital
Pittsburgh, Pennsylvania, United States Recruiting -
UPMC Mercy Hospital
Pittsburgh, Pennsylvania, United States Recruiting -
UPMC Shadyside Hospital
Pittsburgh, Pennsylvania, United States Recruiting -
UPMC Passavant Hospital
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Kathirvel Subramaniam, MD, MPH — University of Pittsburgh
- Study coordinator: Amy Monroe, MPH, MBA
- Email: monroeal@upmc.edu
- Phone: 412-623-6382
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using auricular acupressure to improve health before lung surgery
This study is testing whether auricular acupressure can help improve the health and well-being of people aged 50 and older who are getting ready for major lung surgery.
-
Force feedback in robotic lung resection: does gentler instrument touch help recovery?
This study tests whether using Force Feedback instruments during robotic lobectomy or segmentectomy leads to faster recovery and fewer complications for adults undergoing these procedures.
-
Pre-incisional ropivacaine plus diprospan to relieve pain after VATS
This study tests whether injecting ropivacaine with diprospan before surgery can reduce postoperative pain for adults and children undergoing VATS lung surgery.
-
Left-sided stellate ganglion block to lower post-surgery atrial fibrillation risk
This will test if giving an ultrasound-guided left stellate ganglion block with bupivacaine to adults having esophagectomy, pneumonectomy, or lobectomy lowers their chance of atrial fibrillation after surgery.
-
AirGo Respiratory Monitoring During Lung Resection
Patients undergoing lung resection will wear the AirGo device to continuously monitor breathing before and after surgery to see if it helps track ventilation alongside standard checks.
-
Frailty-focused prehabilitation before heart surgery
This study tests a home-based, frailty-tailored prehabilitation program for adults 65+ waiting 5 weeks or more for heart surgery to see if it improves fitness, frailty, heart-related function, nutrition, inflammation, quality of life, and hospital outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.