Personalized pain management after thoracic surgery
Pharmacogenetics and Pharmacokinetics of Oxycodone to Personalize Postoperative Pain Management Following Thoracic Surgery in Adults
This study is testing a new way to manage pain after lung surgery to see if personalized plans can help patients feel better and use fewer opioids.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | OpalGenix, Inc Industry-sponsored |
| Locations | 4 sites (Pittsburgh, Pennsylvania and 3 other locations) |
| Trial ID | NCT05525923 on ClinicalTrials.gov |
What this trial studies
This research focuses on improving postoperative pain management for adults undergoing thoracic surgery, specifically pneumonectomy, lobectomy, and segmentectomy. It aims to develop personalized risk prediction algorithms to enhance pain relief and reduce opioid use by comparing actual clinical outcomes with predicted outcomes based on individual risk assessments. The study addresses the significant challenges of severe post-surgical pain and the associated risks of opioid use, including chronic pain and opioid dependence. By tailoring pain management strategies, the study seeks to improve recovery and minimize adverse effects.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old, classified as ASA Physical Status 1, 2, or 3, who are scheduled for thoracic surgery.
Not a fit: Patients who are under 18, pregnant, have significant comorbidities, or are undergoing outpatient surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective pain management and reduced opioid-related complications for patients after thoracic surgery.
How similar studies have performed: Other studies have shown promise in personalized pain management approaches, but this specific methodology is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years * American Society of Anesthesiologists (ASA) Physical Status 1, 2, 3 * Undergoing thoracic surgery (TS; pneumonectomy, lobectomy and segmentectomy) Exclusion Criteria: * Children (\<18 years) * Pregnant women * American Society of Anesthesiologists (ASA) Physical Status 4 or above * Non-English speaking * Outpatient surgery * Concomitant additional surgical procedures * Significant liver and kidney dysfunction * Significant cardiorespiratory compromise * Patients with polysubstance use (e.g., cocaine, marijuana, amphetamine, etc.)
Where this trial is running
Pittsburgh, Pennsylvania and 3 other locations
- UPMC Presbyterian Hospital — Pittsburgh, Pennsylvania, United States (Recruiting)
- UPMC Mercy Hospital — Pittsburgh, Pennsylvania, United States (Recruiting)
- UPMC Shadyside Hospital — Pittsburgh, Pennsylvania, United States (Recruiting)
- UPMC Passavant Hospital — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Kathirvel Subramaniam, MD, MPH — University of Pittsburgh
- Study coordinator: Amy Monroe, MPH, MBA
- Email: monroeal@upmc.edu
- Phone: 412-623-6382
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.