Frailty-focused prehabilitation before heart surgery
Official title: A Frailty-specific Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries: A Randomized Sham-controlled Trial
Run by The University of Hong Kong · NCT07824700 · Data updated 2026-11-12
This study tests a home-based, frailty-tailored prehabilitation program for adults 65+ waiting 5 weeks or more for heart surgery to see if it improves fitness, frailty, heart-related function, nutrition, inflammation, quality of life, and hospital outcomes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 144 (estimated) |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | June 4, 2026 |
| Main results expected | April 1, 2027 |
| Study ends | April 7, 2027 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT07824700 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 65+ with mild-to-moderate frailty (Clinical Frailty Scale 4–6) scheduled for elective CABG or valve procedures, with at least 5 weeks before surgery and access to internet-enabled devices.
✕Probably not a fit
Patients who are not frail, have severe frailty (CFs >6), cognitive or communication impairments, or cannot engage in the exercise or electronic device use may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial evaluates a frailty-specific prehabilitation program versus a sham stretching control in frail older adults awaiting elective cardiac surgery (CABG and/or valve procedures). Participants receive education, protein-rich nutrition guidance, relaxation strategies, and structured exercise delivered through home visits, video calls, and self-practice three times per week. Outcomes include functional capacity, frailty status, cardiac function, nutrition markers, inflammation, quality of life, psychological well-being, major cardiovascular events, and readmission rates. The study is conducted in Hong Kong with adults aged 65 and older who have mild-to-moderate frailty and meet other eligibility criteria.
Why it matters
Potential benefit: If successful, the program could improve physical fitness and postoperative recovery for frail cardiac patients.
How similar studies have gone: Prior studies in prehabilitation for cardiac surgery have shown potential benefits, but frailty-tailored, home-based programs are less common and this approach is innovative.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Chinese adult patients scheduled for elective CABG, valve repair/replacement, or combined CABG and valve repair/replacement; * Have mild-to-moderate frailty at the time of recruitment, indicated by a Clinical Frailty Scale score of 4 to 6; * Have at least 5 weeks of procedural waiting time; * Are physically fit for prehabilitation as assessed by the surgeon's/cardiologist's using a risk assessment checklist; * Live with their family; * Are able to use an electronic device with internet access (patient/family). Exclusion Criteria: * Patients with impaired cognition (Abbreviated Mental Test score ≤ 6) or communication, or with physical limitations affecting their ability to exercise
Where it's running
-
School of Nursing, The University of Hong Kong
Hong Kong, Hong Kong Recruiting
Study contacts
- Study coordinator: Polly W.C. Li
- Email: pwcli@hku.hk
- Phone: 852-3917-6686
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.