Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Frailty-focused prehabilitation before heart surgery

Official title: A Frailty-specific Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries: A Randomized Sham-controlled Trial

Run by The University of Hong Kong · NCT07824700 · Data updated 2026-11-12

This study tests a home-based, frailty-tailored prehabilitation program for adults 65+ waiting 5 weeks or more for heart surgery to see if it improves fitness, frailty, heart-related function, nutrition, inflammation, quality of life, and hospital outcomes.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment144 (estimated)
SponsorThe University of Hong Kong
Academic / other
Locations1 site (Hong Kong)
StatusRecruiting
StartedJune 4, 2026
Main results expectedApril 1, 2027
Study endsApril 7, 2027
Registry record updatedSeptember 17, 2026
Trial IDNCT07824700 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults 65+ with mild-to-moderate frailty (Clinical Frailty Scale 4–6) scheduled for elective CABG or valve procedures, with at least 5 weeks before surgery and access to internet-enabled devices.

Probably not a fit

Patients who are not frail, have severe frailty (CFs >6), cognitive or communication impairments, or cannot engage in the exercise or electronic device use may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial evaluates a frailty-specific prehabilitation program versus a sham stretching control in frail older adults awaiting elective cardiac surgery (CABG and/or valve procedures). Participants receive education, protein-rich nutrition guidance, relaxation strategies, and structured exercise delivered through home visits, video calls, and self-practice three times per week. Outcomes include functional capacity, frailty status, cardiac function, nutrition markers, inflammation, quality of life, psychological well-being, major cardiovascular events, and readmission rates. The study is conducted in Hong Kong with adults aged 65 and older who have mild-to-moderate frailty and meet other eligibility criteria.

Why it matters

Potential benefit: If successful, the program could improve physical fitness and postoperative recovery for frail cardiac patients.

How similar studies have gone: Prior studies in prehabilitation for cardiac surgery have shown potential benefits, but frailty-tailored, home-based programs are less common and this approach is innovative.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Chinese adult patients scheduled for elective CABG, valve repair/replacement, or combined CABG and valve repair/replacement;
* Have mild-to-moderate frailty at the time of recruitment, indicated by a Clinical Frailty Scale score of 4 to 6;
* Have at least 5 weeks of procedural waiting time;
* Are physically fit for prehabilitation as assessed by the surgeon's/cardiologist's using a risk assessment checklist;
* Live with their family;
* Are able to use an electronic device with internet access (patient/family).

Exclusion Criteria:

* Patients with impaired cognition (Abbreviated Mental Test score ≤ 6) or communication, or with physical limitations affecting their ability to exercise

Where it's running

  • School of Nursing, The University of Hong Kong
    Hong Kong, Hong Kong
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.