Personalized brain stimulation for treating amphetamine addiction
Official title: Individualized Neuromodulation Intervention Techniques for the Core Clinical Features of Drug Addiction
Run by Shanghai Mental Health Center · NCT06165198 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests a personalized brain stimulation method to see if it can help people addicted to methamphetamine by reducing their cravings more effectively than standard treatments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Shanghai Mental Health Center Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT06165198 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 18 to 45 with a history of amphetamine use for at least one year and who meet DSM-V criteria for addiction severity.
✕Probably not a fit
Patients with severe cognitive impairments, other substance dependencies, or severe mental illnesses may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of closed-loop transcranial alternating current stimulation (tACS) tailored to specific EEG biomarkers in individuals dependent on methamphetamine. By analyzing brain activity related to cravings, the researchers aim to deliver targeted stimulation to the prefrontal cortex and other regions to reduce cravings and improve treatment outcomes. The study compares the effectiveness of this individualized approach against traditional open-loop tACS methods, focusing on the neurological and behavioral effects of the intervention.
Why it matters
Potential benefit: If successful, this approach could significantly reduce cravings and improve treatment outcomes for individuals struggling with amphetamine addiction.
How similar studies have gone: While the approach of using neuromodulation for addiction treatment is gaining traction, this specific individualized method using closed-loop tACS is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals aged between 18 and 45 years, irrespective of gender, having completed a minimum of 9 years of education and capable of effectively cooperating in questionnaire evaluations. * Meet the diagnostic criteria set forth by the DSM-V concerning the severity of amphetamine-type substance addiction. * A history of utilizing amphetamine-type substances for a duration not less than one year, with a frequency of use being at least once per week. * Consent to actively cooperate in the completion of subsequent follow-up assessments. Exclusion Criteria: * Severe cognitive functional impairments manifested through a history of head trauma, cerebrovascular diseases, epilepsy, etc., or usage of cognitive enhancement drugs in the past 6 months; an intellectual disability with an IQ score less than 70. * A diagnosis of schizophrenia or other severe mental illnesses as per the DSM-5 criteria. * Abuse or dependence on other psychoactive substances (excluding nicotine) within the past 5 years. * Severe organic diseases that might compromise study participation. * Contraindications to tACS, such as a history of epileptic seizures or the presence of metallic implants in proximity to the head.
Where it's running
-
Shanghai Mental Health Center
Shanghai, Shanghai, China Recruiting
Study contacts
- Study coordinator: Min Zhao, PhD
- Email: drminzhao@gmail.com
- Phone: 64387250
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Sequential Treatment Approaches for Treatment-Resistant Schizophrenia in Chinese Patients
This trial tests whether clozapine-based drug therapy or neuromodulation with MECT or MST is better for adults in China who have treatment-resistant schizophrenia.
-
Online FBT-DBT for Caregivers of Teens with Anorexia Nervosa
This online program tests a combination of family-based and DBT skills to help caregivers of teens with anorexia nervosa manage stress and improve family support.
-
Temporal Interference stimulation for PTSD symptom relief
This study tests whether Temporal Interference stimulation can help reduce PTSD symptoms in adults with PTSD, using twice-daily sessions over a week and follow-up for up to 3 months.
-
Predicting bipolar disorder relapse risk with multi-modal sentiment analysis
This project tests whether combining speech, facial, and other emotional signals can help predict relapse risk in adults with bipolar disorder.
-
Motion-controlled mobile games to improve thinking in people with schizophrenia
This project will try a motion-based smartphone game to improve thinking skills in adults with stable schizophrenia.
-
Gamified somatosensory and narrative rehabilitation to improve thinking and social skills in hospitalized adults with schizophrenia
This trial will test whether an 8-week gamified digital rehabilitation program can improve cognitive and social functioning for hospitalized adults with schizophrenia and whether benefits last over 24 months.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.