Mapping Epileptic Networks with MRI and iEEG

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop noninvasive imaging biomarkers that can predict the functional dynamics of intracranial EEG (iEEG) and surgical outcomes for patients with intractable epilepsy. By integrating MRI and iEEG data, the researchers seek to create tools that can accurately map epileptic networks, potentially reducing the need for invasive diagnostic procedures. The study focuses on patients with temporal lobe epilepsy who are scheduled for iEEG placement, and it will explore the relationship between structural and functional brain measures and seizure dynamics. The ultimate goal is to enhance patient-specific interventions and improve surgical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with medication-refractory epilepsy
* Planned intracranial EEG (IEEG) placement
* Hypothesized to have temporal lobe epilepsy

Exclusion Criteria:

* Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)

Where it's running

• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Kathryn A Davis, MD, MSTR — University of Pennsylvania
• Study coordinator: Kathryn A Davis, MD, MSTR
• Email: katedavis@pennmedicine.upenn.edu
• Phone: 215-349-5166

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Why People with Epilepsy Get More Infections

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.