Orthosis and Exercise for Grade 1–2 Spondylolisthesis
Official title: The Effect of Orthosis and Exercise Training on Pain, Physical Function and Quality of Life in Patients With Spondylolisthesis
Run by Medipol University · NCT06989138 · Data updated 2026-11-12
This study tests whether stabilization exercise, conventional exercise, or wearing an orthosis can improve pain, physical function, and quality of life in adults with mild spondylolisthesis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | Medipol University Academic / other |
| Locations | 1 site (Istanbul, Istanbul) |
| Status | Recruiting |
| Started | July 26, 2025 |
| Main results expected | November 2026 |
| Study ends | February 2027 |
| Registry record updated | August 3, 2026 |
| Trial ID | NCT06989138 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with grade 1–2 spondylolisthesis who have not had lumbar surgery and do not have severe neurological deficits.
✕Probably not a fit
Patients with different underlying causes of back pain or those who do not respond to conservative management may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants with grade 1–2 spondylolisthesis who have not had surgery or prior lumbar surgery are assigned to one of three conservative approaches: stabilization exercise, conventional exercise, or an orthosis. The trial will measure changes in radiographic findings, pain, physical function, and quality of life over time to see which approach offers the best combination of outcomes. Conservative treatment is standard first-line care, and this study aims to clarify how non-surgical options compare in affecting spinal stability and patient-reported outcomes. No surgical interventions are included unless patients fail conservative care after several months. The study is conducted at Istanbul Medipol University with collaboration from a bone diseases hospital.
Why it matters
Potential benefit: If successful, patients could receive clearer guidance on which non-surgical approach provides the best relief and function for mild spondylolisthesis.
How similar studies have gone: Previous research supports exercise for pain and function in back disorders, but data on radiographic stability and orthosis effects in spondylolisthesis are limited/new.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals aged 18-65 * Individuals without indication for surgery * Individuals diagnosed with grade 1-2 spondylolysis * Individuals without neurological deficits * Individuals diagnosed with radicular pain or non-specific chronic low back pain for more than 3 months Exclusion Criteria: * Surgery recommended after diagnosis * History of lumbar surgery * Presence of rheumatic inflammatory diseases or diabetic polyneuropathy * Individuals with symptoms of cauda equina or ischemic heart disease * Presence of back pain with non-mechanical causes or non-radicular neuropathic pain * Having received this type of exercise therapy before
Where it's running
-
Istanbul Medipol University
Istanbul, Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Fatma Dilge AŞIK BOZDEMİR, Lecturer
- Email: dilge.asik@medipol.edu.tr
- Phone: +90 506 371 44 44
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.