Home › Trials › NCT07729072
Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Olive leaf extract plus endurance training to boost muscle performance in healthy adults

Official title: The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers

Run by University of Lausanne · NCT07729072 · Data updated 2026-11-12

This study tests whether taking olive leaf extract while doing endurance training helps healthy adults improve their exercise performance more than training with a placebo.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment60 (estimated)
SponsorUniversity of Lausanne
Academic / other
Locations1 site (Lausanne)
StatusRecruiting
StartedSeptember 17, 2026
Main results expectedDecember 31, 2028
Study endsDecember 31, 2029
Registry record updatedOctober 8, 2026
Trial IDNCT07729072 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Healthy adults 18-45 who are physically active but not in a structured training program and who pass any PAR-Q screening.

Probably not a fit

Individuals with contraindications to the supplement or who do not respond to training may not experience additional benefits.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this double-blind, randomized trial, healthy adults aged 18-45 will perform three weeks of endurance training (moderate continuous or sprint interval) while receiving olive leaf extract or placebo. The study will look at maximal exercise capacity, knee extensor neuromuscular function, and muscle and blood adaptations to see if olive leaf extract enhances training benefits through effects on mitochondria and neural activation. The investigators hypothesize that the supplement will lead to better performance outcomes compared with training alone. Results may clarify whether olive leaf extract could augment the benefits of regular exercise.

Why it matters

Potential benefit: If positive, the intervention could offer a nutritional strategy to maximize the gains from endurance training.

How similar studies have gone: Prior research suggests polyphenol-rich supplements can influence muscle function and mitochondrial activity; this exact combination with olive leaf extract and endurance training is exploratory.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Being between 18 and 45 years old
2. Being healthy (assessed through the PAR-Q questionnaire).
3. Being physically active, but not involved in any structured training program
4. Being available for the study period.

Exclusion Criteria:

1. If a participant answers positively to any YES/NO question in the PAR-Q health questionnaire. For questions requiring a precision, any positive answer will be reviewed by a medical doctor, who will determine the inclusion/exclusion of the participant.
2. Having allergy to xylocaine
3. Being pregnant.

Where it's running

  • Bâtiment Synathlon, quartier UNIL-Centre
    Lausanne, Switzerland     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
Healthy Adult Participants 56Exercise Training 59Neuromuscular Adaptations 4Nutritional Intervention 5University of Lausanne 5
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.