Estrogen and Exercise to Build Muscle in Postmenopausal Women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study tests whether adding estrogen to a structured exercise program enhances muscle growth and function in postmenopausal women. Participants will be randomized to estrogen or placebo and complete twelve weeks of resistance and aerobic training. Researchers will analyze muscle tissue, stem and support cells, and mitochondrial function to understand how estrogen may influence muscle regeneration and energy use. The study uses in vivo magnetic resonance spectroscopy to assess mitochondrial health during exercise. Preliminary data suggest estrogen may boost muscle protein synthesis, which could lead to new approaches for sarcopenia management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1-10 years since last menstrual bleeding
* Age \> 40 years old
* BMI 20-30

Exclusion Criteria:

* Follicular stimulating hormone \< 30 mmol/L
* Systematic strength training during the last year (\> 1 strength training session per week)
* Injuries to the legs which may prevent participation in the physical training program
* Magnetizable metals or electrical devices implanted in the body, such as a pacemaker
* Use of medication that can influence the effect of immobilization and/or training
* Muscular or joint disorders which may affect the results
* Metabolic diseases (such as diabetes and cardiovascular diseases)
* Previous or present liver or cancer disease
* Current or previous thrombosis
* Porphyria
* Epilepsia
* Systemic autoimmune disease
* Edema
* Smoking or use of other nicotine containing products
* Claustrophobia
* Addictive behavior, defined as abuse of cannabis, opioids, or other intoxicating substances.
* Lack of ability to cooperate
* Blood parameters out of normal range at the health check
* Blood pressure above 140/90 mmHg

Where it's running

• Aarhus University
  Aarhus, Jutland, Denmark Recruiting

Study contacts

• Principal investigator: Mette Hansen, PhD — Aarhus University, Department of Public Health
• Study coordinator: Mette Hansen, PhD
• Email: mhan@ph.au.dk
• Phone: +4551666551

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.