Oral Bisacodyl Before Catheter Insertion to Help Peritoneal Dialysis
Official title: Multi-Centre Pragmatic Randomized Controlled Trial of Bowel Preparation Before Peritoneal Dialysis Catheter Insertion
Run by Chinese University of Hong Kong · NCT07351357 · Data updated 2026-11-12
This study tests whether giving a laxative before Tenckhoff catheter insertion helps keep the catheter flowing smoothly for people starting peritoneal dialysis.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 398 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 6 sites (Kwai Chung, Kowloon and 5 other locations) |
| Status | Recruiting |
| Started | January 12, 2026 |
| Main results expected | August 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | October 21, 2026 |
| Trial ID | NCT07351357 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with kidney failure requiring peritoneal dialysis and scheduled for Tenckhoff catheter insertion.
✕Probably not a fit
Patients who do not experience dysfunction or who cannot tolerate laxatives may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multicenter, open-label randomized controlled trial comparing laxative bowel preparation with standard care before Tenckhoff catheter placement for peritoneal dialysis. The goal is to see if prophylactic bisacodyl reduces catheter dysfunction that requires intervention after surgery. The trial plans to enroll about 199 patients per arm to detect a difference in catheter flow problems between 10% and 20% with 80% power. Primary outcome is catheter dysfunction requiring simple intervention. The study is conducted under the Chinese University of Hong Kong with three Hong Kong hospitals as sites.
Why it matters
Potential benefit: If successful, patients may experience fewer catheter flow problems and fewer interventions after catheter placement.
How similar studies have gone: Other similar approaches have shown potential to reduce postoperative catheter issues, but this specific prophylactic laxative strategy is novel in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * aged 18 or older and need of peritoneal dialysis * willingness to give written consent and comply with the study protocol Exclusion Criteria: * known contraindication to peritoneal dialysis * ongoing diarrhoea or active inflammatory bowel disease * participation in another interventional study within last 30 days of randomization * history of a psychological illness or condition that would interfere with the patient's ability to understand the requirement of the study and/or comply with the dialysis procedures
Where it's running
-
Prince of Wales Hospital
Shatin, Nt, Hong Kong Recruiting -
Princess Margaret Hospital
Kwai Chung, Kowloon, Hong Kong Not yet recruiting -
Caritas Medical Centre
Sham Shui Po, Kowloon, Hong Kong Not yet recruiting -
Tseung Kwan O Hospital
Tseung Kwan O, Nt, Hong Kong Not yet recruiting -
Queen Elizabeth Hospital
Yau Ma Tei, Nt, Hong Kong Not yet recruiting -
Prince of Wales Hospital
Shatin, Hong Kong Not yet recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.