Thiazide diuretics to lower blood pressure in people on peritoneal dialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center treatment-withdrawal crossover trial enrolling 10 chronic peritoneal dialysis patients with uncontrolled hypertension. Participants receive hydrochlorothiazide 25 mg once daily in addition to their usual care for 90 days, followed by a 14-day washout and a 90-day control period. Blood pressure changes (systolic and diastolic) are tracked to compare the on-treatment and off-treatment periods. The study excludes patients with very limited life expectancy or those planning conversion to hemodialysis or kidney transplant within three months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients on chronic peritoneal dialysis, with uncontrolled hypertension (SBP \>140 mmHg and/or DBP \>90 mmHg)

Exclusion Criteria:

* Patients with a life expectancy of less than 3 months, planned conversion to hemodialysis, or scheduled kidney transplantation within 3 months

Where it's running

• Prince of Wales Hospital. The Chinese University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Gordon Chan, MD, MRCP
• Email: cck295@ha.org.hk
• Phone: 0085235052211

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.