Optimizing treatment for acute neonatal hyperammonemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on developing a user-friendly algorithm to optimize the treatment of acute neonatal hyperammonemia, a condition linked to severe neurological outcomes. The approach involves calibrating a single compartmental model based on the patient's total body water and utilizing measured ammonia time-concentration curves during hemodialysis sessions. By calculating dialyzer clearance from ammonia concentration measurements, the study aims to create tailored dialysis protocols suitable for various patient weights and clinical settings. The goal is to improve treatment efficacy and outcomes for affected neonates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* severe acute neonatal hyperammonaemia for which acute hemodialysis is indicated
* inborn error of metabolism
* below 1 year of age

Exclusion Criteria:

* older than 1 year

Where it's running

• Ghent University Hospital - Department of Paediatric Nephrology
  Ghent, Belgium Recruiting

Study contacts

• Study coordinator: Evelien Snauwaert, MD, PhD
• Email: evelien.snauwaert@uzgent.be
• Phone: 00 32 9 332 69 05

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.