Understanding how fatigue and activity change during treatment for advanced or metastatic lung cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study tracks fatigue, physical activity, and related factors in adults with locally advanced, inoperable, or metastatic lung cancer who are beginning first-line systemic therapy. Participants will completed questionnaires on fatigue, breathlessness, sleep, quality of life, stress, anxiety and depression at multiple time points and wear activity monitors and a smartwatch to measure daily activity. They will also provide brief daily smartphone reports on fatigue, breathlessness, pain, and walking ability and undergo physical tests such as a 1-minute sit-to-stand and thigh muscle strength assessments. The goal is to understand how fatigue and activity evolve during treatment and how they relate in the short and long term.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Locally advanced irresectable or metastatic lung cancer (all histologies including NSCLC and SCLC).
* ≥18 years.
* ECOG performance status of ≤2 (a lower score indicates a higher performance status), assessed by the clinician (10).
* Planned to start a first-line systemic treatment consisting of chemotherapy and/or immunotherapy. Patients who receive radiotherapy, concurrently or sequentially, within a multimodality treatment approach for locally advanced lung cancer are allowed.
* Ability to give informed consent.

Exclusion Criteria:

* Being planned for primary radiotherapy with radical intent only or treatment with targeted therapies (mostly tyrosine kinase inhibitors (TKI's)).
* Having complicated or unstable bone metastases (as judged by the clinician).
* Unstable heart disease, including unstable congestive heart failure, arrythmia, or myocardial infarction diagnosed within the last 3 months.
* Other malignancies in the last 2 years (except for adequately treated basal cell, superficial or in situ cancer of the bladder or the cervix).
* Have musculoskeletal problems precluding them to be physically active.
* Not understanding and speaking Dutch.

Where it's running

• UZ Gent
  Ghent, Oost-Vlaanderen, Belgium Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.