Optimizing renal denervation for uncontrolled hypertension
Official title: INtraprocedural Feedback-Optimized Renal Denervation Based on Measurements Obtained Through Renal Artery Stimulation: a Randomized Controlled Proof-of-concept Trial to Assess Whether Renal Denervation Guided by Renal Artery Stimulation Outperforms Conventional Renal Denervation in 6-month Ambulatory Blood Pressure Reductions
Run by National Taiwan University Hospital · NCT06676553 · Data updated 2026-11-12
This study is testing if a new method of renal denervation that uses real-time feedback can help people with high blood pressure more effectively than the standard approach.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 32 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | October 14, 2024 |
| Main results expected | October 31, 2026 |
| Study ends | June 30, 2028 |
| Registry record updated | November 6, 2024 |
| Trial ID | NCT06676553 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with uncontrolled hypertension who are willing to undergo renal denervation and meet specific blood pressure criteria.
✕Probably not a fit
Patients with unsuitable renal artery anatomy or secondary hypertension conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial compares two approaches to renal denervation for patients with uncontrolled hypertension: a guided strategy that involves additional ablations based on real-time feedback from renal artery stimulation, and a conventional approach that does not include repeat procedures. The study aims to determine if the guided strategy leads to better blood pressure outcomes after six months. Patients will undergo renal artery stimulation and radiofrequency ablation using a specialized catheter, with careful monitoring of blood pressure responses throughout the procedure.
Why it matters
Potential benefit: If successful, this approach could significantly improve blood pressure control in patients with resistant hypertension.
How similar studies have gone: Previous studies have shown promising results with renal denervation, but this guided approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with hypertension and are willing to undergo renal denervation. * Patients are treated with antihypertensive medications, or with an office systolic blood pressure (SBP) \>140 mm Hg or diastolic blood pressure (DBP) \>90 mm Hg, and 24-hour SBP of \>130 mmHg or DBP \>80 mm Hg, irrespective of antihypertensive treatment. Exclusion Criteria: * An unsuitable renal artery anatomy for renal denervation, assessed by computed tomographic angiography (main renal artery lumen diameter \<3 mm or a total length \<20 mm). * Secondary hypertension, including hyperaldosteronism, pheochromocytoma, and renal artery stenosis (\>50% stenosis in one or both arteries).
Where it's running
-
National Taiwan University Hospital
Taipei, Taiwan Recruiting
Study contacts
- Principal investigator: Tzung-Dau Wang, MD, PhD — National Taiwan University Hospital
- Study coordinator: Tzung-Dau Wang, MD, PhD
- Email: tdwang@ntu.edu.tw
- Phone: 886-972651070
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.