Opioid-free anesthesia for abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of opioid-free anesthesia versus traditional general anesthesia in patients undergoing abdominal surgery. Participants will be randomly assigned to receive either an opioid-free protocol using medications like Ketamine, Lignocaine, and Dexmedetomidine, or a combined general anesthesia that includes opioids. The primary focus is on assessing pain levels during the first 48 hours post-surgery, as well as measuring total opioid consumption and evaluating postoperative nausea and vomiting. This approach seeks to determine if avoiding opioids can lead to better long-term outcomes, particularly for cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-75 years scheduled for elective urological surgery under general anesthesia: laparoscopic or robotic nephrectomy, laparoscopic or robotic prostatectomy, or laparoscopic or robotic cystectomy.
* Ability to operate a patient-controlled analgesia (PCA) pump postoperatively.
* Ability to understand and use the Numeric Rating Scale (NRS) for pain assessment.
* Written informed consent.

Exclusion Criteria:

* Patient's refusal to participate.
* Inability to operate the PCA pump.
* Inability to understand the NRS pain scale.
* Known hypersensitivity to any of the study drugs (anesthetics, ketamine, dexmedetomidine, ropivacaine, oxycodone, metamizole, paracetamol, ibuprofen).
* Second- or third-degree atrioventricular block, or symptomatic bradycardia.
* Chronic opioid use.
* Contraindication to the planned regional anesthesia technique (e.g. coagulopathy or therapeutic anticoagulation, infection at the puncture site).

Where it's running

• Jagiellonian University
  Krakow, Lesser Poland Voivodeship, Poland Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.