Opioid-free anesthesia for abdominal surgery
Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery
This study is testing whether using an opioid-free anesthesia for abdominal surgery can help patients feel less pain and have fewer side effects compared to traditional anesthesia that includes opioids.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Jagiellonian University Academic / other |
| Locations | 1 site (Kraków, Malopolskie) |
| Trial ID | NCT06380244 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of opioid-free anesthesia versus traditional general anesthesia in patients undergoing abdominal surgery. Participants will be randomly assigned to receive either an opioid-free protocol using medications like Ketamine, Lignocaine, and Dexmedetomidine, or a combined general anesthesia that includes opioids. The primary focus is on assessing pain levels during the first 48 hours post-surgery, as well as measuring total opioid consumption and evaluating postoperative nausea and vomiting. This approach seeks to determine if avoiding opioids can lead to better long-term outcomes, particularly for cancer patients.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for abdominal surgery who consent to participate in the study.
Not a fit: Patients who refuse to participate, cannot operate a PCA pump, or have hypersensitivity to anesthetic drugs may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce chronic postoperative pain and improve quality of life for surgical patients.
How similar studies have performed: While opioid-free anesthesia is used in practice, there is limited conclusive scientific data confirming its advantages specifically for abdominal surgery, making this study a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient's consent to participate in the study * surgery within the abdominal cavity Exclusion Criteria: * patient's refusal to participate in the study * inability to operate the PCA pump * not understanding how the NRS scale works * hypersensitivity to anesthetic drugs * 1st or 2nd degree heart block.
Where this trial is running
Kraków, Malopolskie
- Jagiellonian University — Kraków, Malopolskie, Poland (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.