Oxygen or low-pressure CPAP applied to the non-ventilated lung during lung resection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, controlled, blinded trial enrolls 177 adults undergoing elective lung resection and one-lung ventilation with a double-lumen tube. Participants are assigned to one of three arms: standard oxygen per routine practice, apneic oxygenation delivered through a probe in the double-lumen tube, or low-pressure CPAP (2 cm H2O with 3–5 L/min O2) via a Mapleson system. Investigators will measure inflammatory mediators in blood and both lungs intraoperatively and 24 hours after surgery, and will follow patients until hospital discharge and again at 30 days. The trial compares effects on inflammatory response, ischemia–reperfusion injury, oxygenation, and postoperative complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of both genders undergoing lung resection surgery in the Thoracic Surgery Department at Hospital General Universitario Gregorio Marañón
* Lung isolation using a double-lumen tube (DLT)
* Scheduled surgery
* Patients able and willing to give written informed consent
* Patients over 18 years old and legally competent

Exclusion Criteria:

* Patients with evidence of pulmonary bullae
* Pregnancy or breastfeeding
* Blood transfusion within 10 days prior to surgery
* Treatment with immunosuppressants or corticosteroids within 3 months prior to surgery
* Patient refusal to participate
* Prior contralateral thoracic surgery
* Robotic surgery
* Pneumonectomy
* Enrollment in another clinical trial

Where it's running

• Hospital General Universitario Gregorio Marañón
  Madrid, Spain Recruiting

Study contacts

• Principal investigator: Francisco de la Gala, MD, PhD — Hospital General Universitario Gregorio Marañon
• Study coordinator: Francisco de la Gala, MD, PhD
• Email: francisco.gala@salud.madrid.org
• Phone: +34915868367

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.