Observing patients with severe COPD exacerbations in the ICU
Official title: Epidemiological, Clinical and Biological Characteristics, and Therapeutic Management of ICU Patients With Severe Acute Exacerbation of COPD. Evaluation of Prognosis and Factors Associated With Survival.
Run by Versailles Hospital · NCT06257329 · Data updated 2026-11-12
This study looks at patients with severe COPD flare-ups in the ICU to learn more about their health, treatments, and chances of recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Versailles Hospital Academic / other |
| Locations | 4 sites (Grenoble and 3 other locations) |
| Status | Recruiting |
| Started | October 1, 2022 |
| Main results expected | October 1, 2027 |
| Study ends | April 1, 2028 |
| Registry record updated | October 27, 2026 |
| Trial ID | NCT06257329 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 40 and older with documented or suspected COPD who are experiencing a severe acute exacerbation requiring ICU admission.
✕Probably not a fit
Patients with known asthma or those who refuse to participate will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study aims to describe the epidemiological, clinical, and biological characteristics of patients admitted to the ICU for severe acute exacerbations of COPD. It will assess the various therapeutic approaches used and evaluate patient prognosis over short, medium, and long-term periods, including factors associated with survival in the ICU. Data will be collected from pseudonymized medical files, ensuring compliance with legal and ethical standards. The study has received favorable ethical approval and aims to enhance understanding of COPD exacerbations in critical care settings.
Why it matters
Potential benefit: If successful, this study could improve treatment strategies and outcomes for patients experiencing severe COPD exacerbations.
How similar studies have gone: While this study follows a common observational approach, the specific focus on severe COPD exacerbations in ICU settings may provide novel insights, as similar studies have shown varying degrees of success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 40 years old 2. COPD documented or strongly suspected * Chronic respiratory symptoms (dyspnoea, cough and/or sputum) * Exposure to a known risk factor for COPD (such as tobacco smoke) * If available, respiratory function tests showing non- or partially reversible obstructive syndrom (post-bronchodilator ratio FEV1/CV \< 0.7) 3. Severe acute exacerbation, defined as a worsening of the patient's usual respiratory symptoms with signs of acute respiratory distress (polypnoea ≥ 30 cycles.min-1 or use of accessory respiratory muscles) and/or hypercapnic acidosis (with PaCO2 ≥ 45 mmHg and pH ≤ 7.35) 4. Admission to an ICU, a step-up unit or a respiratory care unit Exclusion Criteria: 1. Known asthma (according to the criteria of the international "Global initiative for asthma" guidelines) 2. Patient refusal to participate (information note, application for non-opposition)
Where it's running
-
CHU de Grenoble
Grenoble, France Recruiting -
Centre hospitalier de Versailles
Le Chesnay, France Recruiting -
CH Le Mans
Le Mans, France Recruiting -
CHU Rennes
Rennes, France Recruiting
Study contacts
- Study coordinator: Alexis Ferré, M.D.
- Email: aferre@ght78sud.fr
- Phone: +33.1.39.63.887.00
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.