Observational study on Ewing's sarcoma of the bone
Observational Study on Treatment of Skeletal Ewing Sarcoma at Diagnosis
This study is collecting information from patients with Ewing's sarcoma to learn more about the disease and improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 0 Years to 49 Years |
| Sex | All |
| Sponsor | Italian Sarcoma Group Research network |
| Drugs / interventions | chemotherapy |
| Locations | 19 sites (Rozzano, MI and 18 other locations) |
| Trial ID | NCT04845893 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect comprehensive data on the demographic, clinical, surgical, pathological, and molecular characteristics of patients diagnosed with skeletal Ewing's sarcoma. The study will gather information on treatment approaches, including chemotherapy, surgery, and radiotherapy, to better understand the disease's biological behavior and improve treatment strategies. By analyzing data from patients with localized and metastatic disease, the study seeks to enhance knowledge that could inform future clinical trials and treatment protocols.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with Ewing's sarcoma of the bone or related conditions, aged under 50 years.
Not a fit: Patients with significant comorbidities that may hinder treatment compliance or outcome evaluation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies and outcomes for patients with Ewing's sarcoma.
How similar studies have performed: While there have been limited randomized studies on Ewing's sarcoma, this observational approach builds on decades of clinical experience and previous trials, suggesting potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Diagnosis of Ewing's sarcoma of the bone 2. Diagnosis of Ewing-like sarcoma (round cell sarcoma with fusion of the EWSR1 gene with others not of the ETS family, sarcoma with CIC rearrangement or sarcoma with BCOR rearrangement) 3. Diagnosis of extraosseous Ewing's sarcoma for patients 4. Age at diagnosis \<50 years 5. Assessment of the extent of the disease at onset in accordance with the European Society of Medical Oncology guidelines 6. Patients or parents oe guardians of minors who have given their written informed consent to participate in the study Exclusion Criteria: 1\. Presence of comorbid factors who can compromise the compliance of the treatment plan or the evaluation of the outcomes, including but not limited to organ pathologies that contraindicate the use of chemotherapy and psychological or social conditions that do not allow for adequate compliance treatment or adequate follow-up
Where this trial is running
Rozzano, MI and 18 other locations
- Istituto Clinico Humanitas — Rozzano, Mi, Italy (Recruiting)
- Centro di Riferimento Oncologico - Unit of Medical Oncology — Aviano, Pordenone, Italy (Recruiting)
- I.R.C.C. - Unit of Medical Oncology — Candiolo, Torino, Italy (Recruiting)
- Azienda ospedaliero universitaria consorziale policlinico - bari — Bari, Italy (Recruiting)
- A.O. Universitaria Policlinico S. Orsola Malpighi di Bologna — Bologna, Italy (Recruiting)
- Istituto ortopedico Rizzoli — Bologna, Italy (Recruiting)
- A.O. Universitaria Meyer — Florence, Italy (Recruiting)
- Istituto Giannina Gaslini — Genova, Italy (Recruiting)
- FONDAZIONE IRCCS Istituto Nazionale dei Tumori — Milan, Italy (Recruiting)
- FONDAZIONE IRCCS Istituto Nazionale dei Tumori — Milan, Italy (Recruiting)
- Azienda Ospedaliera Santobono Pausilipon — Naples, Italy (Not_yet_recruiting)
- Azienda Ospedaliera di Padova — Padova, Italy (Recruiting)
- ARNAS P. O. "Civico e Benfratelli" — Palermo, Italy (Recruiting)
- Azienda Ospedaliera Universitaria di Parma — Parma, Italy (Recruiting)
- Azienda Ospedaliero-Universitaria Pisana — Pisa, Italy (Recruiting)
- Ospedale Pediatrico Bambin Gesu' — Roma, Italy (Not_yet_recruiting)
- Istituto Regina Elena - IFO — Rome, Italy (Recruiting)
- Ospedale Infantile Regina Margherita - Unit of Paediatric Oncoematology — Torino, Italy (Recruiting)
- IRCCS materno infantile Burlo Garofolo — Trieste, Italy (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.