Observational study of localized angiosarcoma
Official title: Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars
Run by Italian Sarcoma Group · NCT06375941 · Data updated 2026-11-12
This study is trying to find the best ways to treat localized angiosarcoma by looking at how patients are managed across different hospitals in Italy.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | Italian Sarcoma Group Research network |
| Drugs / interventions | radiation |
| Locations | 19 sites (Rozzano, Milano and 18 other locations) |
| Status | Recruiting |
| Started | March 29, 2024 |
| Main results expected | April 1, 2029 |
| Study ends | April 1, 2034 |
| Registry record updated | November 20, 2025 |
| Trial ID | NCT06375941 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals of any age with a pathological diagnosis of localized, resectable angiosarcoma.
✕Probably not a fit
Patients with non-localized or unresectable angiosarcoma may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multi-institutional, prospective observational study focusing on patients with localized primary angiosarcoma (AS) across various sites. The study aims to standardize and better define the management of localized AS, particularly regarding the roles of radiation therapy and systemic treatment. By collecting clinical and pathological data from patients treated at reference centers in Italy, the study seeks to address existing gaps in knowledge about treatment approaches and prognostic factors for this rare cancer. The collaboration involves the Italian Sarcoma Group and the Italian Rare Cancer Network to enhance the quality of care for patients with rare tumors.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols and outcomes for patients with localized angiosarcoma.
How similar studies have gone: While studies on angiosarcoma are limited due to its rarity, similar observational approaches in other rare cancers have shown promise in improving treatment understanding.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * pathological diagnosis of AS; * any site of origin; * any age; * primary, localized, resectable disease. Exclusion Criteria: NA
Where it's running
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Centro Riferimento Oncologico CRO
Aviano, Pordenone, Italy Recruiting -
AOU San Luigi Gonzaga
Orbassano, Torino, Italy Recruiting -
Istituto Ortopedico Rizzoli IOR
Bologna, Italy Recruiting -
Policlinico "Sant'Orsola-Malpighi"
Bologna, Italy Recruiting -
Ospedale Policlinico san Martino IRCCS
Genova, Italy Recruiting -
IRCCS Istituto Nazionale Tumori - Milano
Milan, Italy Recruiting
Show 13 more locations
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Istituto Nazionale Tumori_Fondazione "G.Pascale"
Naples, Italy Recruiting -
IOV Istituto Oncologico Veneto IRCCS
Padova, Italy Recruiting -
Policlinico "Paolo Giaccone"
Palermo, Italy Recruiting -
Nuovo Ospedale di Prato - S. Stefano
Prato, Italy Recruiting -
Fondazione Policlinico Campus Biomedico
Roma, Italy Recruiting -
ASL Ospedale San Giovanni Bosco
Torino, Italy Recruiting -
Istituto Clinico Humanitas Research Hospital IRCCS
Rozzano, Milano, Italy Not yet recruiting -
Istituto Tumori "Giovanni Paolo II" I.R.C.C.S.
Bari, Italy Not yet recruiting -
A.O.U. Careggi
Florence, Italy Not yet recruiting -
IRCCS Istituto Europeo di Oncologia
Milan, Italy Not yet recruiting -
Fondazione Irccs San Gerardo Dei Tintori
Monza, Italy Not yet recruiting -
IRCCS Istituti Fisioterapici Ospitalieri
Roma, Italy Not yet recruiting -
Ospedale di Trento
Trento, Italy Not yet recruiting
Study contacts
- Principal investigator: Elena Palassini — IRCCS Istituto nazionale Tumori - Milano
- Study coordinator: Gianluca Ignazzi
- Email: gianluca.ignazzi@italiansarcomagroup.org
- Phone: +393335359192
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.