Clinical trial Recruiting at 12 sites Observational

Observational study of localized angiosarcoma

Official title: Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars

Run by Italian Sarcoma Group · NCT06375941 · Data updated 2026-11-12

This study is trying to find the best ways to treat localized angiosarcoma by looking at how patients are managed across different hospitals in Italy.

Quick facts

Study typeObservational
SexAll
Enrollment250 (estimated)
SponsorItalian Sarcoma Group
Research network
Drugs / interventionsradiation
Locations19 sites (Rozzano, Milano and 18 other locations)
StatusRecruiting
StartedMarch 29, 2024
Main results expectedApril 1, 2029
Study endsApril 1, 2034
Registry record updatedNovember 20, 2025
Trial IDNCT06375941 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals of any age with a pathological diagnosis of localized, resectable angiosarcoma.

Probably not a fit

Patients with non-localized or unresectable angiosarcoma may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multi-institutional, prospective observational study focusing on patients with localized primary angiosarcoma (AS) across various sites. The study aims to standardize and better define the management of localized AS, particularly regarding the roles of radiation therapy and systemic treatment. By collecting clinical and pathological data from patients treated at reference centers in Italy, the study seeks to address existing gaps in knowledge about treatment approaches and prognostic factors for this rare cancer. The collaboration involves the Italian Sarcoma Group and the Italian Rare Cancer Network to enhance the quality of care for patients with rare tumors.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment protocols and outcomes for patients with localized angiosarcoma.

How similar studies have gone: While studies on angiosarcoma are limited due to its rarity, similar observational approaches in other rare cancers have shown promise in improving treatment understanding.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* pathological diagnosis of AS;
* any site of origin;
* any age;
* primary, localized, resectable disease.

Exclusion Criteria: NA

Where it's running

  • Centro Riferimento Oncologico CRO
    Aviano, Pordenone, Italy
    Recruiting
  • AOU San Luigi Gonzaga
    Orbassano, Torino, Italy
    Recruiting
  • Istituto Ortopedico Rizzoli IOR
    Bologna, Italy
    Recruiting
  • Policlinico "Sant'Orsola-Malpighi"
    Bologna, Italy
    Recruiting
  • Ospedale Policlinico san Martino IRCCS
    Genova, Italy
    Recruiting
  • IRCCS Istituto Nazionale Tumori - Milano
    Milan, Italy
    Recruiting
Show 13 more locations
  • Istituto Nazionale Tumori_Fondazione "G.Pascale"
    Naples, Italy
    Recruiting
  • IOV Istituto Oncologico Veneto IRCCS
    Padova, Italy
    Recruiting
  • Policlinico "Paolo Giaccone"
    Palermo, Italy
    Recruiting
  • Nuovo Ospedale di Prato - S. Stefano
    Prato, Italy
    Recruiting
  • Fondazione Policlinico Campus Biomedico
    Roma, Italy
    Recruiting
  • ASL Ospedale San Giovanni Bosco
    Torino, Italy
    Recruiting
  • Istituto Clinico Humanitas Research Hospital IRCCS
    Rozzano, Milano, Italy
    Not yet recruiting
  • Istituto Tumori "Giovanni Paolo II" I.R.C.C.S.
    Bari, Italy
    Not yet recruiting
  • A.O.U. Careggi
    Florence, Italy
    Not yet recruiting
  • IRCCS Istituto Europeo di Oncologia
    Milan, Italy
    Not yet recruiting
  • Fondazione Irccs San Gerardo Dei Tintori
    Monza, Italy
    Not yet recruiting
  • IRCCS Istituti Fisioterapici Ospitalieri
    Roma, Italy
    Not yet recruiting
  • Ospedale di Trento
    Trento, Italy
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.