Non-invasive neuromodulation for patients with Long-COVID

Effectiveness of Non-invasive Neuromodulation Compared to Placebo on Sleep Quality in Patients With Post-COVID Symptoms: a Randomized Clinical Trial.

Not applicable Interventional Universidad Rey Juan Carlos · NCT06456502

This study is testing if a new non-invasive treatment can help people with Long-COVID improve their sleep and overall well-being.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment44 (estimated)
Ages18 Years and up
SexAll
SponsorUniversidad Rey Juan Carlos Academic / other
Locations1 site (Alcorcón, Madrid)
Trial IDNCT06456502 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of non-invasive neuromodulation techniques in improving sleep quality and overall well-being in patients suffering from Long-COVID or post-acute COVID-19 syndrome. Participants will receive either the neuromodulation treatment or a placebo, with the aim of assessing changes in sleep quality, mood, and cognitive function. The study focuses on individuals who have experienced symptoms for at least six months following their initial COVID-19 infection. By examining the physiological effects of improved sleep, the study seeks to address the broader impacts of Long-COVID on health.

Who should consider this trial

Good fit: Ideal candidates are individuals diagnosed with Long-COVID or post-acute COVID syndrome who have experienced symptoms for at least six months.

Not a fit: Patients who are pregnant, have pacemakers, or suffer from certain neurological or cardiovascular conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly enhance sleep quality and overall health outcomes for patients suffering from Long-COVID.

How similar studies have performed: While the specific application of non-invasive neuromodulation for Long-COVID is novel, similar approaches have shown promise in improving sleep and cognitive function in other populations.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Subjects with long COVID or post- acute COVID syndrome
* With a evolution of at least 6 months after acute SARS-cov-2 infection
* Whit symptoms present at baseline.

Exclusion Criteria:

* Pregnancy.
* Pacemakers
* Ulcerations or wounds in the area of electrode application.
* Decompensated heart disease.
* Epilepsy and/or choreic syndromes.
* Frequent medication with corticosteroids, hypnotics or supplements such as melatonin, Ashwagandha or phosphatidylserine.
* Hypersensitivity on hands and feet that influence the use of the gloves and socks from the neuromodulation system.

Where this trial is running

Alcorcón, Madrid

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Long-COVIDPost-acute COVID-19 SyndromePost acute COVID-19 syndromeNon-invasive neuromodulationSleep qualityDepressionAnxietyFatigue
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.