Multi-omics program to understand complications and outcomes after aneurysmal subarachnoid hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational project collects blood, cerebrospinal fluid, urine, and other biospecimens from adults with confirmed aneurysmal subarachnoid hemorrhage whose aneurysm is secured within 72 hours. Genomic, transcriptomic, proteomic, metabolomic, and imaging-omic profiling will be performed and integrated with detailed clinical and imaging data. The analysis will link molecular signatures to secondary complications such as delayed cerebral ischemia and pneumonia and to longer-term neurological outcomes. Results aim to identify pathways and biomarkers that explain outcome differences and support development of predictive tools or targeted interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult patients aged ≥18 years;
2. Confirmed diagnosis of aneurysmal subarachnoid hemorrhage (aSAH) by CTA, or DSA;
3. Aneurysm secured by either microsurgical clipping or endovascular coiling during hospitalization;
4. Time from onset to aneurysm treatment ≤ 72 hours;
5. Availability of biospecimens, including blood, cerebrospinal fluid (CSF), urine, or fecal samples collected during hospitalization;
6. Signed informed consent obtained from the patient or legal representative.

Exclusion Criteria:

1. History of previous intracranial aneurysm surgery or embolization;
2. Non-aneurysmal SAH, traumatic SAH, or perimesencephalic non-aneurysmal hemorrhage;
3. Presence of malignancy, severe hepatic or renal dysfunction, or other systemic diseases that may affect survival or biomarker expression;
4. Severe cardiorespiratory insufficiency or unstable medical condition precluding study participation;
5. Pregnancy or lactation;
6. Refusal to participate or withdrawal of consent.

Where it's running

• Beijing Tiantan Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Runting Li, MD
• Email: tt18080lrt@163.com
• Phone: +86 15753166690

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Nitric Oxide Use to Predict Vasospasm in Aneurysmal Subarachnoid Hemorrhage

  This study tests whether nitric oxide consumption in CSF can predict cerebral vasospasm in patients with aneurysmal SAH.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07614906

• Dome-only coiling for severe aneurysmal subarachnoid hemorrhage

  This will test a minimally invasive dome-protection coiling procedure to prevent re-bleeding in adults who have had a severe aneurysmal subarachnoid hemorrhage.

  Recruiting University of Louisville · Louisville, Kentucky · NCT07250958

• Cilostazol to help prevent delayed brain ischemia after aneurysm bleed

  This study tests whether cilostazol can reduce delayed brain ischemia and improve outcomes after aneurysmal subarachnoid hemorrhage in adults who had recent aneurysm treatment.

  Recruiting Phase 3 Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07249853

• Transcutaneous Vagal Nerve Stimulation to help with brain vessel narrowing after aneurysm rupture

  This trial tests whether using a noninvasive nerve stimulation device can reduce cerebral vasospasm after an aneurysmal brain bleed in adults 18–65 who are undergoing standard treatment.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07131696

• Tocilizumab-aazg to reduce stroke risk after a ruptured brain aneurysm

  This trial will try to see if a single IV dose of tocilizumab-aazg is safe and can help prevent delayed strokes in adults who have had a ruptured brain aneurysm (aneurysmal subarachnoid hemorrhage).

  Recruiting Phase 1 University of Florida · Gainesville, Florida · NCT06863480

• Using human albumin to improve outcomes in patients with aneurysmal subarachnoid hemorrhage

  This study is testing if giving human albumin to patients with a type of brain hemorrhage can help improve their recovery compared to standard fluid treatments.

  Recruiting Hamad Medical Corporation · Doha · NCT06548477

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.