Nicardipine for rapid systolic BP control in intracerebral hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This quality improvement study uses a quasi-randomized design to implement a treatment algorithm that prioritizes intravenous antihypertensives like nicardipine over transdermal nitrate patches. The goal is to increase the proportion of patients reaching a systolic BP target of less than 140 mmHg within 1 hour of hospital admission while monitoring safety, clinical outcomes, and resource use. The approach reflects existing guideline emphasis on rapid BP control in acute ICH and builds on prior signals about potential harms from early nitrate patches. The study is conducted at Aarhus University Hospital with lead sponsorship from the same institution.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Acute spontaneous Intracerberal Hemorrhage confirmed by imaging
* Symptom onset to stroke center admission \<6 hours
* Elevated systolic blood pressure (\>140 mmHg) at admission

Exclusion Criteria:

* Secondary causes of ICH (e.g., trauma, vascular malformation)
* Presumed fatal bleeding at admission
* Short remaining life expectancy (\<12 month)

Where it's running

• Aarhus University Hospital
  Aarhus, Denmark Recruiting

Study contacts

• Study coordinator: Rolf Blauenfeldt, MD, PhD
• Email: rolfblau@rm.dk
• Phone: +4520774053

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.