New non-invasive method for selecting embryos in IVF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to improve embryo selection during in vitro fertilization (IVF) by using a novel non-invasive approach that combines morphokinetic analysis with Raman spectroscopy. In the first phase, archived data will be analyzed to train a convolutional neural network (CNN) for embryo selection. The second phase will involve a randomized controlled trial to assess the effectiveness of this integrated method in increasing clinical pregnancy rates. The approach promises to provide a quicker and more cost-effective alternative to traditional invasive genetic testing methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients undergoing IVF/ ICSI treatment
2. Patients receiving the first, second or third IVF/ICSI treatment cycle
3. Patients and their partners willing to sign the informed consent agreement
4. Patients having at least three normal fertilised embryos on the day of the fertilization check
5. Consecutive women undergoing IVF treatment
6. Patients planning to use a time-lapse incubator for embryo culture

Exclusion Criteria:

1. Day one human embryos with blur imaging
2. Large obstructions in the embryo area
3. More than half of the embryo area is blocked by the well or degeneration
4. Patients with more than half of the embryos without sufficient spent culture medium for RS analysis
5. Patients with known genetic diseases

Where it's running

• The Chinese University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Pui Wah Jacqueline Chung — Chinese University of Hong Kong
• Study coordinator: Pui Wah Jacqueline Chung
• Email: jacquelinechung@cuhk.edu.hk
• Phone: +852 35051537

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• AI tool to analyze sperm and predict their ability to help IVF/ICSI succeed

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.