Titania nanoparticle–infused fluoride varnish vs conventional fluoride varnish for plaque control in fixed braces
Official title: Comparing the Antiplaque Efficacy of Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients-A Triple Blind Randomised Controlled Trial.
Run by Pakistan Institute of Medical Sciences · NCT07180849 · Data updated 2026-11-12
This will test whether a fluoride varnish that contains titania nanoparticles reduces dental plaque more than regular fluoride varnish in people aged 16–30 who are starting fixed orthodontic braces.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 16 Years to 30 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Pakistan Institute of Medical Sciences Government |
| Locations | 1 site (Islamabad) |
| Status | Recruiting |
| Started | November 2025 |
| Main results expected | July 2027 |
| Study ends | December 2027 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT07180849 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people aged 16–30 who are planning to start fixed orthodontic treatment, have no active periodontal disease, no prior orthodontic treatment, and are not taking antibiotics.
✕Probably not a fit
Patients with active periodontal disease, currently on antibiotic therapy, with craniofacial abnormalities, mixed dentition, or who cannot attend the Islamabad site are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional trial compares a novel fluoride varnish loaded with titania nanoparticles synthesized from Moringa oleifera leaf extract to a conventional fluoride varnish in patients receiving multibracket fixed orthodontic treatment. Participants aged 16–30 with no prior orthodontic treatment or active periodontal disease are randomized to receive one of the two varnishes applied during their orthodontic care. The study measures antiplaque and antibiofilm effects over time using clinical plaque indices and likely microbiological assays to track changes in biofilm. Patients on antibiotics, with craniofacial abnormalities, or with mixed dentition are excluded.
Why it matters
Potential benefit: If successful, the nanoparticle-enhanced varnish could better prevent plaque buildup around braces and reduce the risk of cavities and gum problems during orthodontic treatment.
How similar studies have gone: Laboratory and small clinical studies of titania and other nanoparticle-enhanced dental materials have shown antibacterial effects, but direct clinical comparisons in fixed orthodontic patients remain limited and relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Patients planned for fixed orthodontic treatment. * Patients within age group 16-30 years. * Patient with no history of previous orthodontic treatment. * Patients with no active periodontal diseases. Exclusion criteria: * Patient undergoing any antibiotic therapy. * Patients with any craniofacial abnormality. * Patient with mixed dentition
Where it's running
-
Pakistan Institute of Medical Sciences
Islamabad, Pakistan Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.