Monitoring miscarriage through a blood test
Official title: Non-invasive Monitoring of Miscarriage
Run by Chinese University of Hong Kong · NCT06581692 · Data updated 2026-11-12
This study is testing a blood test that looks at DNA to see if it can help understand the genetic reasons behind miscarriages in women who have had early pregnancy loss, especially those who used fertility treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | September 1, 2024 |
| Main results expected | August 31, 2039 |
| Study ends | August 31, 2039 |
| Registry record updated | November 12, 2024 |
| Trial ID | NCT06581692 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18-45 who attend an early pregnancy loss clinic or have received ART.
✕Probably not a fit
Patients with a history of psychological or psychiatric problems or those who refuse participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on the use of cell-free DNA (cfDNA) to identify chromosomal causes of miscarriages during early pregnancy. It compares cfDNA levels obtained from a simple blood test with results from product of conception (POC) testing and standard karyotyping. The study specifically targets women who have experienced early pregnancy loss, particularly those who have undergone assisted reproductive technologies (ART). By analyzing cfDNA, the study aims to provide insights into the genetic factors contributing to miscarriages.
Why it matters
Potential benefit: If successful, this approach could lead to a non-invasive method for diagnosing chromosomal abnormalities in miscarriages, improving patient care and understanding.
How similar studies have gone: Other studies have shown promise in using cfDNA for genetic analysis, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-45 years. 2. Women who attend the early pregnancy loss clinic or Patients who receive ART 3. Their partner, the biological father of the pregnancy Exclusion Criteria: * History of psychological/ psychiatric problem * Patient refusal
Where it's running
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Prince of Wales Hospital
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Pui Wah Jacqueline Chung — Chinese University of Hong Kong
- Study coordinator: Pui Wah Jacqueline Chung
- Email: jacquelinechung@cuhk.edu.hk
- Phone: +852 35051764
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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See if non-invasive fetal DNA testing after early miscarriage supports mental health and follow-up care
This study tests whether doing non-invasive prenatal testing from a blood sample after an early miscarriage helps with mental well-being and guides care over the next year.
-
Comprehensive assessment of first-trimester miscarriage causes and consequences
This project will test genetic, hormonal, immune, cardiovascular, placental, and psychological factors in women who had a miscarriage before 14 weeks to see what may have caused it and how it affects their health.
-
Letrozole plus misoprostol compared with misoprostol alone for treating missed miscarriage
This trial will test whether taking letrozole for three days before misoprostol helps women up to 13 weeks with a missed miscarriage pass the pregnancy completely more often than misoprostol alone.
-
Hysteroscopic removal versus manual vacuum aspiration for early miscarriage
This trial will test whether hysteroscopic resection or ultrasound-guided manual vacuum aspiration works better to remove pregnancy tissue in women with a first-trimester miscarriage under 9 weeks who choose surgical management.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.