Monitoring miscarriage through a blood test
Non-invasive Monitoring of Miscarriage
This study is testing a blood test that looks at DNA to see if it can help understand the genetic reasons behind miscarriages in women who have had early pregnancy loss, especially those who used fertility treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06581692 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the use of cell-free DNA (cfDNA) to identify chromosomal causes of miscarriages during early pregnancy. It compares cfDNA levels obtained from a simple blood test with results from product of conception (POC) testing and standard karyotyping. The study specifically targets women who have experienced early pregnancy loss, particularly those who have undergone assisted reproductive technologies (ART). By analyzing cfDNA, the study aims to provide insights into the genetic factors contributing to miscarriages.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-45 who attend an early pregnancy loss clinic or have received ART.
Not a fit: Patients with a history of psychological or psychiatric problems or those who refuse participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to a non-invasive method for diagnosing chromosomal abnormalities in miscarriages, improving patient care and understanding.
How similar studies have performed: Other studies have shown promise in using cfDNA for genetic analysis, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-45 years. 2. Women who attend the early pregnancy loss clinic or Patients who receive ART 3. Their partner, the biological father of the pregnancy Exclusion Criteria: * History of psychological/ psychiatric problem * Patient refusal
Where this trial is running
Hong Kong
- Prince of Wales Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Pui Wah Jacqueline Chung — Chinese University of Hong Kong
- Study coordinator: Pui Wah Jacqueline Chung
- Email: jacquelinechung@cuhk.edu.hk
- Phone: +852 35051764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.