Comprehensive assessment of first-trimester miscarriage causes and consequences

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational project enrolling 225 women with a missed miscarriage before 14 weeks at Hospital de la Santa Creu i Sant Pau in Barcelona. Participants are divided into first-time miscarriage and recurrent pregnancy loss groups and will undergo clinical evaluation and biosample collection. Analyses will include genetic testing, measurement of angiogenic and hormonal markers, immune and cardiovascular assessments, placental studies, and psychological screening. The goal is to link multi-domain findings to underlying causes and inform personalized follow-up and support.

Why it matters

Who can join: the full rules

Female participants:

Inclusion Criteria:

* Women aged 18 years or older.
* Diagnosis of missed miscarriage in the first trimester (\<14 weeks of gestation) confirmed by ultrasound.
* Presence of an intrauterine pregnancy with fetal demise (clinical pregnancy loss).
* Willing and able to provide written informed consent.
* Ability to understand and complete study procedures.

Exclusion Criteria:

* Multiple pregnancy (twins or more).
* Ectopic pregnancy.
* Molar pregnancy (complete or partial hydatidiform mole).
* Ongoing pregnancy with fetal cardiac activity.
* Inability or unwillingness to comply with study procedures or follow-up.

Male participants: no specific inclusion or exclusion criteria will apply to male partners, since the main inclusion criteria is a clinical pregnancy loss.

Where it's running

• Hospital de la Santa Creu i Sant Pau
  Barcelona, Barcelona, Spain Recruiting
• Hospital de la Santa Creu i Sant Pau
  Barcelona, Barcelona, Spain Not yet recruiting

Study contacts

• Study coordinator: Cristina Trilla Solà, MD, PhD
• Email: ctrilla@santpau.cat
• Phone: 0034935537050

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• Monitoring miscarriage through a blood test

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.