Letrozole plus misoprostol compared with misoprostol alone for treating missed miscarriage
Official title: Comparison of Letrozole With Misoprostol Versus Misoprostol Alone in the Management of Missed Miscarriages
Run by Nishtar Medical University · NCT07160855 · Data updated 2026-11-12
This trial will test whether taking letrozole for three days before misoprostol helps women up to 13 weeks with a missed miscarriage pass the pregnancy completely more often than misoprostol alone.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 92 (estimated) |
| Sponsor | Nishtar Medical University Academic / other |
| Locations | 1 site (Multan, Punjab Province) |
| Status | Recruiting |
| Started | May 13, 2025 |
| Main results expected | November 12, 2025 |
| Study ends | November 12, 2025 |
| Registry record updated | September 8, 2025 |
| Trial ID | NCT07160855 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women up to 13 weeks' gestation with a single intrauterine missed miscarriage who are planning termination and have no prior cesarean or uterine scar would be ideal candidates.
✕Probably not a fit
People with prior cesarean section or other uterine scarring, multiple pregnancy, or pregnancies beyond 13 weeks are excluded and would not be expected to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, controlled Phase 4 trial will enroll 92 women with a single missed miscarriage up to 13 weeks' gestation and assign them to receive either letrozole for three days followed by vaginal misoprostol or misoprostol with a placebo. The main outcomes are the rate of complete uterine evacuation and the time to expulsion after treatment. Women with a prior cesarean section or other uterine scar are excluded. Care and follow-up visits are conducted at Nishtar Medical University and Hospital in Multan.
Why it matters
Potential benefit: If successful, the combination could raise the chance of a complete medical management of missed miscarriage and reduce the need for surgical procedures.
How similar studies have gone: Smaller trials and observational reports using letrozole or other pretreatments before misoprostol for early pregnancy termination have shown mixed but sometimes promising improvements in expulsion rates, so evidence is limited but suggestive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women up till 13th weeks of gestation according to last menstrual period (LMP) dates, confirmed on ultrasound * Single intrauterine pregnancy * Planned for termination due to missed miscarriage Exclusion Criteria: * Previous history of cesarean section * Uterine scar due to previous procedure like myomectomy
Where it's running
-
Nishtar Medical University and Hospital
Multan, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Afrayshum T Principal Investigator, MBBS
- Email: afrayshumtariq@gmail.com
- Phone: +92 3336239197
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
See if non-invasive fetal DNA testing after early miscarriage supports mental health and follow-up care
This study tests whether doing non-invasive prenatal testing from a blood sample after an early miscarriage helps with mental well-being and guides care over the next year.
-
Comprehensive assessment of first-trimester miscarriage causes and consequences
This project will test genetic, hormonal, immune, cardiovascular, placental, and psychological factors in women who had a miscarriage before 14 weeks to see what may have caused it and how it affects their health.
-
Hysteroscopic removal versus manual vacuum aspiration for early miscarriage
This trial will test whether hysteroscopic resection or ultrasound-guided manual vacuum aspiration works better to remove pregnancy tissue in women with a first-trimester miscarriage under 9 weeks who choose surgical management.
-
Monitoring miscarriage through a blood test
This study is testing a blood test that looks at DNA to see if it can help understand the genetic reasons behind miscarriages in women who have had early pregnancy loss, especially those who used fertility treatments.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.