Monitoring FSH levels to optimize ovarian stimulation
Assessment of the Role of Serum FSH Monitoring During Ovarian Stimulation and Identification of an Optimal Range for Expected Normal Responders
This study is testing if keeping track of FSH hormone levels can help improve the success of ovarian stimulation for women trying to conceive.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 39 Years |
| Sex | Female |
| Sponsor | ART Fertility Clinics LLC Academic / other |
| Locations | 1 site (Abu Dhabi, Abu Dhabi Emirate) |
| Trial ID | NCT06572930 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of serum Follicle Stimulating Hormone (FSH) levels in predicting oocyte yield and progesterone levels during ovarian stimulation. It considers various factors such as age, baseline FSH, Antral Mullerian Hormone (AMH), antral follicle count, body weight, kidney function, and urinary FSH. The goal is to identify a minimum FSH level that ensures optimal ovarian response, allowing for tailored FSH dosages to improve outcomes. By focusing on FSH monitoring, the study aims to enhance the effectiveness of ovarian stimulation protocols.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 21 to 39 with regular menstrual cycles, a specific BMI range, and certain ovarian reserve indicators.
Not a fit: Patients with conditions such as hypogonadotropic hypogonadism, history of ovarian surgery, or those older than 39 years may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective ovarian stimulation protocols, improving fertility outcomes for patients.
How similar studies have performed: While the approach of monitoring FSH levels is not widely tested, similar studies have shown promise in optimizing ovarian stimulation protocols.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * regular 21 - 35 days cycles * BMI between 19 - 30 kg/m2 * serum AMH level between 1.5 to 3 ng/ml * a total antral follicle count between 10 to 24 * endogenous early follicular phase serum FSH level \<10 IU/L * normal glomerular filtration rate Exclusion Criteria: * hypogonadotropic hypogonadism * history of ovarian surgery * permanent ovarian cysts of any form * older than 39 years * abnormal thyroid stimulating hormone (TSH) * renal disease * elevated prolactin levels * intake of oral contraceptives 3 months before stimulation start and estradiol pretreatment will be excluded
Where this trial is running
Abu Dhabi, Abu Dhabi Emirate
- ART Fertility Clinics — Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates (Recruiting)
Study contacts
- Study coordinator: Jonalyn Edades
- Email: jonalyn.edades@artfertilityclinics.com
- Phone: +971526408688
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.