Clinical trial Recruiting at 1 site Observational Ages 18 to 90

Bedside measurement of lung collapse and reopening in people on invasive mechanical ventilation

Official title: Bed Side Assessment in Patients With Acute Respiratory Failure Under Invasive Mechanical Ventilation

Run by Fondazione IRCCS Policlinico San Matteo di Pavia · NCT07265882 · Data updated 2026-11-12

This project will try using ventilator-recorded pressure and volume data to measure how much lung tissue opens with inhalation and then collapses again with exhalation in people on passive invasive mechanical ventilation for acute respiratory failure.

More Acute Respiratory Failure (ARF) trials

Quick facts

Study typeObservational
Ages18 Years to 90 Years
SexAll
Enrollment100 (estimated)
SponsorFondazione IRCCS Policlinico San Matteo di Pavia
Academic / other
Locations1 site (Pavia, Pavia)
StatusRecruiting
StartedNovember 14, 2022
Main results expectedJuly 1, 2026
Study endsNovember 1, 2026
Registry record updatedDecember 5, 2025
Trial IDNCT07265882 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with acute respiratory failure who are sedated and passively receiving invasive mechanical ventilation, without hemodynamic instability or confirmed intracranial hypertension, would be the appropriate candidates.

Probably not a fit

Patients who are hemodynamically unstable, have confirmed intracranial hypertension, or are not passively ventilated (spontaneously breathing) are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational, single-center study collects ventilator data from patients receiving passive invasive mechanical ventilation to characterize respiratory mechanics, with particular focus on lung tissue that repeatedly opens and closes (lung instability). Investigators perform offline analysis of low-flow pressure–volume loops derived from ventilator maneuvers to quantify recruitment and derecruitment. Patients with hemodynamic instability or confirmed intracranial hypertension are excluded. No experimental interventions are applied; the work aims to refine bedside measurements that might guide future ventilator strategies.

Why it matters

Potential benefit: If successful, the measurements could help clinicians identify unstable lung regions and better tailor ventilator settings to reduce repetitive lung collapse and potentially improve outcomes.

How similar studies have gone: Similar bedside approaches using pressure–volume loops and respiratory mechanics have been explored and shown promise for identifying recruitable lung, but their impact on patient outcomes remains variable and largely investigational.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients undergoing passive mechanical ventilation

Exclusion Criteria:

* hemodynamic instability
* confirmed intracranial hypertension

Where it's running

  • Fondazione IRCCS Policlinico San Matteo
    Pavia, Pavia, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.