Bedside measurement of lung collapse and reopening in people on invasive mechanical ventilation
Official title: Bed Side Assessment in Patients With Acute Respiratory Failure Under Invasive Mechanical Ventilation
Run by Fondazione IRCCS Policlinico San Matteo di Pavia · NCT07265882 · Data updated 2026-11-12
This project will try using ventilator-recorded pressure and volume data to measure how much lung tissue opens with inhalation and then collapses again with exhalation in people on passive invasive mechanical ventilation for acute respiratory failure.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, Pavia) |
| Status | Recruiting |
| Started | November 14, 2022 |
| Main results expected | July 1, 2026 |
| Study ends | November 1, 2026 |
| Registry record updated | December 5, 2025 |
| Trial ID | NCT07265882 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with acute respiratory failure who are sedated and passively receiving invasive mechanical ventilation, without hemodynamic instability or confirmed intracranial hypertension, would be the appropriate candidates.
✕Probably not a fit
Patients who are hemodynamically unstable, have confirmed intracranial hypertension, or are not passively ventilated (spontaneously breathing) are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational, single-center study collects ventilator data from patients receiving passive invasive mechanical ventilation to characterize respiratory mechanics, with particular focus on lung tissue that repeatedly opens and closes (lung instability). Investigators perform offline analysis of low-flow pressure–volume loops derived from ventilator maneuvers to quantify recruitment and derecruitment. Patients with hemodynamic instability or confirmed intracranial hypertension are excluded. No experimental interventions are applied; the work aims to refine bedside measurements that might guide future ventilator strategies.
Why it matters
Potential benefit: If successful, the measurements could help clinicians identify unstable lung regions and better tailor ventilator settings to reduce repetitive lung collapse and potentially improve outcomes.
How similar studies have gone: Similar bedside approaches using pressure–volume loops and respiratory mechanics have been explored and shown promise for identifying recruitable lung, but their impact on patient outcomes remains variable and largely investigational.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients undergoing passive mechanical ventilation Exclusion Criteria: * hemodynamic instability * confirmed intracranial hypertension
Where it's running
-
Fondazione IRCCS Policlinico San Matteo
Pavia, Pavia, Italy Recruiting
Study contacts
- Study coordinator: Marco Pozzi, MD
- Email: ma.pozzi@smatteo.pv.it
- Phone: +39 0382503711
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Weaning HFNC: When to Stop High-Flow Oxygen in Acute Respiratory Failure
This study tests a protocol to guide when to stop high-flow nasal therapy in adults with acute respiratory failure who are already on HFNC.
-
Monitoring breathing muscle function in ARF patients on non-invasive support
This study tests whether advanced breathing-muscle monitoring can help care teams manage adults with acute respiratory failure who are on non-invasive respiratory support.
-
Comparing 3D/2D electrical impedance tomography and the R/I ratio to measure lung recruitability during mechanical ventilation
This test tries to see if two imaging methods (3D and 2D electrical impedance tomography) and a pressure-based recruitment-to-inflation (R/I) ratio give consistent estimates of how much the lungs can be recruited in sedated adults on mechanical ventilation for acute respiratory failure.
-
Home oxygen with high-flow therapy vs standard oxygen for chronic lung and heart disease
In people with long-term lung or heart conditions who need oxygen after leaving the hospital, the study tests whether a high-flow nasal cannula (HFNC) can improve breathing comfort and quality of life compared with standard oxygen therapy.
-
Music therapy to ease pain during noninvasive ventilation in children
This trial will try using a structured music program to lower pain and improve comfort for children (0–17) who are starting noninvasive ventilation in the pediatric intensive care unit.
-
Assessing Diaphragm Activity and Breathing Mechanics During NAVA Ventilation
This study is testing if a special type of breathing support called NAVA can help lung transplant patients breathe better and protect their lungs while they recover in the ICU.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.