Bedside measurement of lung collapse and reopening in people on invasive mechanical ventilation
Bed Side Assessment in Patients With Acute Respiratory Failure Under Invasive Mechanical Ventilation
This project will try using ventilator-recorded pressure and volume data to measure how much lung tissue opens with inhalation and then collapses again with exhalation in people on passive invasive mechanical ventilation for acute respiratory failure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, Pavia) |
| Trial ID | NCT07265882 on ClinicalTrials.gov |
What this trial studies
This observational, single-center study collects ventilator data from patients receiving passive invasive mechanical ventilation to characterize respiratory mechanics, with particular focus on lung tissue that repeatedly opens and closes (lung instability). Investigators perform offline analysis of low-flow pressure–volume loops derived from ventilator maneuvers to quantify recruitment and derecruitment. Patients with hemodynamic instability or confirmed intracranial hypertension are excluded. No experimental interventions are applied; the work aims to refine bedside measurements that might guide future ventilator strategies.
Who should consider this trial
Good fit: Adults with acute respiratory failure who are sedated and passively receiving invasive mechanical ventilation, without hemodynamic instability or confirmed intracranial hypertension, would be the appropriate candidates.
Not a fit: Patients who are hemodynamically unstable, have confirmed intracranial hypertension, or are not passively ventilated (spontaneously breathing) are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the measurements could help clinicians identify unstable lung regions and better tailor ventilator settings to reduce repetitive lung collapse and potentially improve outcomes.
How similar studies have performed: Similar bedside approaches using pressure–volume loops and respiratory mechanics have been explored and shown promise for identifying recruitable lung, but their impact on patient outcomes remains variable and largely investigational.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients undergoing passive mechanical ventilation Exclusion Criteria: * hemodynamic instability * confirmed intracranial hypertension
Where this trial is running
Pavia, Pavia
- Fondazione IRCCS Policlinico San Matteo — Pavia, Pavia, Italy (Recruiting)
Study contacts
- Study coordinator: Marco Pozzi, MD
- Email: ma.pozzi@smatteo.pv.it
- Phone: +39 0382503711
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.