Moderate breathing and movement: Can regular exercise help people with quiescent inflammatory bowel disease feel better?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, interventional study will compare adults aged 18 to 65 with clinically quiescent inflammatory bowel disease to see if regular moderate exercise affects quality of life over six months. It will also explore whether exercise-related changes in clinical symptoms correspond with blood and stool inflammatory markers, and how physical activity relates to sleep, stress, and body composition. Participants must have stable treatment and access to online tools; those with conditions that limit exercise or with advanced cardiac or organ disease will be excluded. The study is led by Mahidol University and conducted at Siriraj Hospital in Bangkok, focusing on exercise as the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with Crohn's disease or Ulcerative colitis.
* Aged between 18 and 65 years.
* Disease must be in clinical remission for at least 2 months prior to study enrollment, as defined by: Crohn's disease: Harvey-Bradshaw Index \< 5 Ulcerative colitis: Mayo Ulcerative Colitis Subscore \< 2
* Not currently receiving corticosteroids,
* If receiving immunomodulators or biologic therapy, the treatment regimen must be stable for at least 2 months prior to enrollment.
* Participants must have access to and be capable of using online communication tools and digital platforms.

Exclusion Criteria:

* Patients with medical conditions that limit the ability to exercise, including Severe joint pain or inflammatory arthritis affecting ambulation or mobility Advanced cardiac disease (New York Heart Association Class ≥ 2) Chronic lung disease or pulmonary hypertension Liver cirrhosis Chronic kidney disease stage 3 or higher

Poorly controlled non-communicable diseases, such as:

Hypertension (BP ≥ 160/100 mmHg) Diabetes mellitus with poor glycemic control (HbA1c ≥ 9% or requiring insulin therapy)

* Patients who already engage in moderate-intensity exercise for more than 60 minutes per week on a regular basis.
* Pregnant individuals or those planning to become pregnant during the study period.
* Patients planning to undergo treatment changes or surgery within the next 3 months, or who have had surgery within the past 6 months.

Where it's running

• Faculty of Medicine Siriraj Hospital
  Bangkok Noi, Bangkok, Thailand Recruiting

Study contacts

• Principal investigator: Julajak Limsrivilai, MD, MSc — Mahidol University
• Study coordinator: Jirateep Tuntichamnankul, MD
• Email: jirateeptuntikul2@gmail.com
• Phone: +66 0858570247

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.